P. Rehling

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

Profiling the LAM family of contact site tethers provides insights into their regulation and function

The paper profiles the LAM family of contact site tethers to understand their localization and function, revealing unique and shared roles through proximity labeling.

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Delta/+ mice hearts

The Drosophila MIC10 orthologue has a propensity to polymerize into cristae-shaping filaments

This study identifies DmMIC10b as the major MIC10 orthologue in Drosophila, showing it polymerizes into cristae-shaping filaments that affect mitochondrial structure and fly lifespan.

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

This study identifies ORF3c as a SARS-CoV-2 protein that localizes to mitochondria and inhibits IFN-β production without affecting NF-κB or JAK-STAT signaling.

A quantitative fluorescence-based approach to study mitochondrial protein import

This paper introduces a fluorescence-based method for analyzing mitochondrial protein import with high sensitivity and quantification capabilities.

Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel metazoan specific complex III assembly factor

This study identifies OCIAD2 as a novel metazoan-specific complex III assembly factor, showing its role in mitochondrial function and its deregulation in cancer and neurodegenerative disorders.

Local translation in synaptic mitochondria influences synaptic transmission

The paper uses an imaging approach to study mitochondrial translation in neurons, finding it occurs in dendrites and axons, correlates with synaptic activity, and affects synaptic function.

Inhibition of proteasomal degradation rescues a pathogenic variant of mitochondrial Respiratory chain assembly 1 factor

This study shows that inhibiting proteasome degradation rescues mutant RESA1 protein function and complex IV activity in patient-derived fibroblasts.