Author

L. E. A. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:metabolomics· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

R. C. Sun· 4 shared M. S. Gentry· 2 shared A. Dhara· 1 shared A. L. Dube· 1 shared A. P. Sinai· 1 shared A. Patwardhan· 1 shared A. Tripathi· 1 shared B. Kelly· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersCell Biology

R. C. Sun

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in Toxoplasma gondii tachyzoites and bradyzoites

R. D. Murphy, C. A. Troublefield, J. S. Miracle, L. E. A. Young, A. Tripathi, C. O. Brizzee, A. Dhara, A. Patwardhan, R. C. Sun, C. W. Vander Kooi, M. S. Gentry, A. P. Sinai

This study investigates the role of TgLaforin, a glucan phosphatase, in Toxoplasma gondii by showing its impact on glucan metabolism, virulence, and bradyzoite survival during chronic infection.

bioRxiv · Sep 29, 2023 · PreprintMicrobiology

In Situ Microwave Fixation to Define the Terminal Rodent Brain Metabolome

J. A. Juras, M. B. Webb, L. E. A. Young, K. H. Markussen, T. R. Hawkinson, M. D. Buoncristiani, K. E. Bolton, P. T. Coburn, M. I. Wiliams, L. P. Sun, W. C. Sanders, R. C. Bruntz, L. R. Conroy, C. Wang, M. S. Gentry, , R. C. Sun

This study uses microwave fixation to preserve brain metabolites in mice, showing reduced glucose metabolism in diabetic models and altered metabolic enzyme expression.

bioRxiv · Aug 16, 2022 · PreprintBiochemistry

A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate

M. J. Xiao, C.-H. Wu, G. Meek, B. Kelly, L. E. A. Young, S. Martire, D. B. Castillo, P. Saha, A. L. Dube, M. Gentry, L. A. Banaszynski, R. C. Sun, C. KIKANI

This study identifies a mechanism by which mitochondrial glutamine metabolism links cell cycle progression to stem cell fate decisions through PASK and WDR5 interactions.

bioRxiv · Mar 24, 2022Cell Biology

Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools

N. L. Hepowit, J. K. A. Macedo, L. E. A. Young, K. Liu, R. C. Sun, J. MacGurn, R. C. Dickson

This study shows that pharmacologically lowering amino acid pools in yeast extends lifespan by inhibiting TORC1 signaling through sphingolipid-dependent mechanisms.

bioRxiv · Oct 30, 2020Cell Biology