Author

N. L. Hepowit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Assay:proteomics· 4 Organism:yeast· 3 Approach:biophysical modeling· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

J. A. MacGurn· 3 shared R. C. Dickson· 2 shared B. J. Moon· 1 shared B. Xie· 1 shared E. R. Strieter· 1 shared J. Best· 1 shared J. Du· 1 shared J. K. A. Macedo· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCell Biology

J. A. MacGurn

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Author profile →

4 papers

Recent·Most cited

Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion

N. L. Hepowit, B. J. Moon, R. C. Dickson, J. A. MacGurn

The paper shows that sphingolipid depletion causes selective endocytosis of methionine transporters via Art2-mediated ubiquitination, altering nutrient transporter composition at the cell surface.

bioRxiv · May 20, 2022Cell Biology

Ubiquitination drives COPI priming and Golgi SNARE localization

S. S. Date, P. Xu, N. L. Hepowit, N. S. Diab, J. Best, B. Xie, J. Du, E. R. Strieter, L. P. Jackson, J. A. MacGurn, T. R. Graham

The paper identifies ubiquitin recognition by COPI as essential for Golgi SNARE localization and stabilizing interactions between Arf, COPI, and SNAREs.

bioRxiv · Nov 29, 2021Cell Biology

Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools

N. L. Hepowit, J. K. A. Macedo, L. E. A. Young, K. Liu, R. C. Sun, J. MacGurn, R. C. Dickson

This study shows that pharmacologically lowering amino acid pools in yeast extends lifespan by inhibiting TORC1 signaling through sphingolipid-dependent mechanisms.

bioRxiv · Oct 30, 2020Cell Biology

Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast

N. L. Hepowit, K. N. Pereira, J. M. Tumolo, W. J. Chazin, J. A. MacGurn

This study identifies Ser57 ubiquitin kinases in yeast and human cells that regulate the oxidative stress response by phosphorylating ubiquitin at Ser57.

bioRxiv · Jun 20, 2020Cell Biology