Author

L. E. Crowell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

A. M. Biedermann· 2 shared C. A. Whittaker· 2 shared J. C. Love· 2 shared M. K. Tracey· 2 shared N. C. Dalvie· 2 shared S. A. Rodriguez-Aponte· 2 shared A. Bonnyman· 1 shared C. A. Naranjo· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBioengineering

A. M. Biedermann

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Author profile →

2 papers

Recent·Most cited

Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered Komagataella phaffii

N. C. Dalvie, A. M. Biedermann, S. A. Rodriguez-Aponte, C. A. Naranjo, H. D. Rao, M. P. Rajurkar, R. R. Lothe, U. S. Shaligram, R. S. Johnston, L. E. Crowell, S. Castelino, M. K. Tracey, C. A. Whittaker, J. C. Love

This paper describes an engineered Komagataella phaffii strain for methanol-free production of SARS-CoV-2 RBD, achieving a 5x increase in secreted titer and enabling scalable manufacturing for vaccine development.

bioRxiv · Apr 15, 2021Bioengineering

Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

N. C. Dalvie, J. R. Brady, L. E. Crowell, M. K. Tracey, A. M. Biedermann, K. Kaur, J. M. Hickey, D. L. Kristensen, A. Bonnyman, S. A. Rodriguez-Aponte, C. A. Whittaker, M. Bok, C. Vega, T. Mukhopadhyay, S. B. Joshi, , J. C. Love

The paper engineers subunit antigens to improve vaccine manufacturing by reducing variants and enabling single-process production of a trivalent rotavirus vaccine.

bioRxiv · Nov 20, 2020Bioengineering