Author
S. A. Rodriguez-Aponte
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2020-2022 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author links6 papers
Recent·Most cited
- BioengineeringbioRxiv
Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffii
N. C. Dalvie, C. A. Naranjo, S. A. Rodriguez-Aponte…·J. C. Love
The paper improves recombinant protein secretion quality and titer in Komagataella phaffii by modifying the N-terminus to enhance steric accessibility of the signal peptide.
DOI 10.1186/s12934-022-01905-2 - ImmunologybioRxivPreprint
A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates
N. C. Dalvie, L. H. Tostanoski, S. A. Rodriguez-Aponte…·D. H. Barouch
This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.
DOI 10.1101/2021.07.13.452251 - MicrobiologybioRxiv
Modular development enables rapid design of media for alternative hosts
A. M. Biedermann, I. R. Gengaro, S. A. Rodriguez-Aponte…·J. C. Love
The paper introduces a modular media design approach for rapid optimization of cell growth and protein production in Pichia pastoris using high-throughput fermentations and an open-source automation tool.
DOI 10.1002/bit.27947 - BioengineeringbioRxiv
Scalable, methanol-free manufacturing of the SARS-CoV-2 receptor binding domain in engineered Komagataella phaffii
N. C. Dalvie, A. M. Biedermann, S. A. Rodriguez-Aponte…·J. C. Love
This paper describes an engineered Komagataella phaffii strain for methanol-free production of SARS-CoV-2 RBD, achieving a 5x increase in secreted titer and enabling scalable manufacturing for vaccine development.
DOI 10.1002/bit.27979 - BioengineeringbioRxiv
Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus
N. C. Dalvie, J. R. Brady, L. E. Crowell…·J. C. Love
The paper engineers subunit antigens to improve vaccine manufacturing by reducing variants and enabling single-process production of a trivalent rotavirus vaccine.
DOI 10.1186/s12934-021-01583-6