Author

L. Ghita

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. A. Pinsky· 3 shared S. Einav· 3 shared A. Narayanan· 2 shared J. Jin· 2 shared M. K. Sahoo· 2 shared M. Karim· 2 shared N. Bhalla· 2 shared S. De Jonghe· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

B. A. Pinsky

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Global and cell type-specific immunological hallmarks of severe dengue progression

L. Ghita, Z. Yao, Y. Xie, V. Duran, B. H. Cagirici, J. Samir, I. Osman, O. L. Agudelo, A. M. Sanz, M. K. Sahoo, M. Robinson, R. M. Gelvez, N. Bueno, F. Luciani, B. A. Pinsky, , S. Einav

This study identifies DENV target cells and immunological changes in severe dengue progression using single-cell RNA-Seq and functional assays in children.

bioRxiv · Dec 11, 2022 · PreprintImmunology

Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy

M. Karim, S. Saul, L. Ghita, M. K. Sahoo, C. Ye, N. Bhalla, J. Jin, J.-G. Park, B. Martinez-Gualda, M. Patrick East, G. L. Johnson, B. A. Pinsky, L. Martinez-Sobrido, C. R. M. Asquith, A. Narayanan, , S. Einav

This study shows that Numb-associated kinases are essential for SARS-CoV-2 infection and that inhibiting them can suppress viral infection in human lung cells.

bioRxiv · Mar 18, 2022 · PreprintMicrobiology

Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen

S. Saul, M. Karim, P.-T. Huang, L. Ghita, W. Chiu, S. Kumar, N. Bhalla, P. Leyssen, C. A. Cohen, K. E. Huie, C. Tindle, M. Sibai, B. A. Pinsky, S. Das, P. Ghosh, , S. Einav

This study identifies lapatinib, an ErbB inhibitor, as a broad-spectrum antiviral that suppresses SARS-CoV-2 and VEEV replication, inflammation, and lung injury through ErbB-mediated mechanisms.

bioRxiv · May 15, 2021Microbiology

Sequential MAVS- and MyD88/TRIF-signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes

L. Ghita, V. Breitkopf, F. Mulenge, A. Pavlou, O. L. Gern, V. Duran, C. K. Prajeeth, M. Kohls, K. Jung, M. Stangel, I. Steffen, U. Kalinke

This study identifies astrocytes as key IFN-β producers in TBEV-infected mice, showing biphasic IFN-β induction dependent on MAVS and later MyD88/TRIF signaling.

bioRxiv · Jun 30, 2020Immunology