Author

G. L. Johnson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. P. East· 4 shared T. Laitinen· 3 shared A. Poso· 2 shared B. A. Pinsky· 2 shared C. I. Wells· 2 shared C. R. M. Asquith· 2 shared D. H. Drewry· 2 shared L. Ghita· 2 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersPharmacology & Toxicology

M. P. East

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2

M. Karim, M. Mishra, C.-W. Lo, S. Saul, H. B. Cagirici, D. H. Nhu Tran, A. Agrawal, L. Ghita, A. Ojha, M. P. East, K. Anbro Gammeltoft, M. Kumar Sahoo, G. L. Johnson, S. Das, D. Jochmans, , S. Einav

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

bioRxiv · Apr 15, 2024Microbiology

Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships

C. R. M. Asquith, M. P. East, T. Laitinen, C. Alamillo-Ferrer, E. Hartikainen, C. I. Wells, A. D. Axtman, D. H. Drewry, G. J. Tizzard, A. Poso, T. M. Willson, G. L. Johnson

The paper identifies and optimizes narrow-spectrum TLK2 inhibitors using QSAR analysis and structural studies.

bioRxiv · Dec 28, 2023Pharmacology & Toxicology

Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy

M. Karim, S. Saul, L. Ghita, M. K. Sahoo, C. Ye, N. Bhalla, J. Jin, J.-G. Park, B. Martinez-Gualda, M. Patrick East, G. L. Johnson, B. A. Pinsky, L. Martinez-Sobrido, C. R. M. Asquith, A. Narayanan, , S. Einav

This study shows that Numb-associated kinases are essential for SARS-CoV-2 infection and that inhibiting them can suppress viral infection in human lung cells.

bioRxiv · Mar 18, 2022 · PreprintMicrobiology

Limited inhibition of multiple nodes in a driver network blocks metastasis

A. E. Yesilkanal, D. Yang, P. Tiwari, A. U. Sabino, J. Lee, X.-H. Xie, S. Sun, C. Dann, E. Steinberg, T. Stuhlmiller, C. Frankenberger, E. Goldsmith, G. L. Johnson, A. F. Ramos, M. R. Rosner

The paper shows that limited inhibition of multiple core pathways in a driver network effectively blocks metastasis in mouse breast cancer models.

bioRxiv · Jun 5, 2020Cancer Biology

Design of a GAK/EGFR inhibitor set to interrogate the relationship of EGFR and GAK in chordoma

C. Asquith, K. Naegeli, M. P. East, T. Laitinen, T. M. Havener, C. I. Wells, G. L. Johnson, D. H. Drewry, W. J. Zuercher, D. C. Morris

The paper designs a set of GAK/EGFR inhibitors to study their relationship in chordoma and characterizes their activity in vitro and through target engagement assays.

bioRxiv · Nov 20, 2018Pharmacology & Toxicology

Proteomic Analysis Defines Kinase Taxonomies Specific For Subtypes Of Breast Cancer

K. A. Collins, T. J. Stuhlmiller, J. S. Zawistowski, M. P. East, T. T. Pham, C. R. Hall, D. R. Goulet, S. M. Bevill, S. P. Angus, S. H. Velarde, N. Sciaky, T. I. Oprea, L. M. Graves, G. L. Johnson, S. M. Gomez

The paper uses proteomic analysis to define kinase taxonomies specific to breast cancer subtypes, revealing understudied kinases and their functional integration into signaling subnetworks.

bioRxiv · Sep 15, 2017Cancer Biology