I. Osman

CRISPR-inhibition screen for lncRNAs linked to melanoma growth and metastasis

The paper identifies lncRNAs involved in melanoma growth and metastasis using CRISPR-inhibition screens and validates their functional roles.

Gut microbiome is associated with recurrence-free survival in patients with resected Stage IIIB-D or Stage IV melanoma treated with immune checkpoint inhibitors

The paper identifies gut microbiome taxonomic markers associated with recurrence in melanoma patients treated with immune checkpoint inhibitors, showing generalizability across regions when GMB composition is matched.

Integrated in vivo functional screens and multi-omics analyses identify alpha-2,3-sialylation as essential for melanoma maintenance

Global and cell type-specific immunological hallmarks of severe dengue progression

This study identifies DENV target cells and immunological changes in severe dengue progression using single-cell RNA-Seq and functional assays in children.

Recurrence of cancer cell states across diverse tumors and their interactions with the microenvironment

The paper identifies recurrent cancer cell states across 15 tumor types and examines their interactions with the tumor microenvironment using single-cell RNA-Seq and spatial transcriptomics.

A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

A Deep Learning Approach for Rapid Mutational Screening in Melanoma

This paper develops a deep learning model to detect BRAF mutations in melanoma histopathology images using whole slide images from 256 patients, achieving AUC scores of 0.96 and 0.72.

Melanoma-secreted Amyloid Beta Supresses Neuroinflammation and Promotes Brain Metastasis

This study identifies amyloid beta as a factor secreted by melanoma cells that suppresses neuroinflammation and promotes brain metastasis.