M. J. Evans

Local and global density have distinct and parasite-dependent effects on infection in wild sheep

The paper examines how local and global density affect parasite infection in wild sheep, finding distinct effects depending on age and parasite type.

Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors

The paper identifies fragment binders and mutationally intolerant sites in Zika virus NS2B-NS3 protease to develop resistance-resilient antiviral inhibitors.

The effect of single mutations in Zika virus envelope on escape from broadly neutralizing antibodies

This study identifies how single mutations in Zika virus envelope protein affect neutralization by broadly and narrowly specific antibodies, finding that broad antibodies are harder to escape.

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis.

This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.

CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer

This paper evaluates CDCP1 as a target for radioligand therapy in mCRPC, showing its expression in most biopsies and demonstrating antitumor effects with 177Lu-4A06.

Targeting a proteolytic neo-epitope of CUB-domain containing protein 1 in RAS-driven cancer

The paper develops antibodies targeting proteolytic neo-epitopes of CDCP1 in RAS-driven cancers, showing improved tumor specificity and safety.

Linking mountaintop removal mining to water quality for imperiled species using satellite data

The paper links mountaintop removal mining to water quality degradation in streams critical for imperiled species using satellite data and water quality monitoring.

Unpacking the eagle collision risk model: practical guidance for wind energy

The paper evaluates how prior information and survey effort affect eagle fatality predictions in wind energy permits and translates these into financial costs.

Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

This paper develops FeADCs, ferrous iron-activatable drug conjugates, to target KRAS-driven cancers with improved tumor selectivity and systemic tolerability.

Recovery units under the Endangered Species Act could be used more widely

The paper analyzes the use of recovery units under the Endangered Species Act, finding they are underutilized and could improve species recovery by focusing on wide-ranging, well-studied species.

Automated Change Detection Methods for Satellite Data that can Improve Conservation Implementation

This paper develops and evaluates automated methods for detecting land cover changes using satellite data to aid in conservation monitoring and enforcement.

30 years of satellite data show imperiled species are most vulnerable to habitat loss on private lands

The paper uses satellite data to show imperiled species lose more habitat on private lands than federal lands, highlighting the need for better conservation on private lands.

Deep mutational scanning comprehensively maps how Zika envelope protein mutations affect viral growth and antibody escape

This study uses deep mutational scanning to map how Zika virus envelope protein mutations affect viral growth and antibody escape, revealing detailed functional and antigenic constraints.

Zika Virus Subverts Stress Granules to Promote and Restrict Viral Gene Expression

This study investigates how Zika virus disrupts stress granule formation and modulates viral gene expression by relocalizing specific stress granule proteins.

Data indicate the importance of expert agencies in conservation policy.

The paper analyzes NMFS consultation data under the ESA to show federal agencies often misestimate impacts on listed species, highlighting the importance of expert agency input.