Author

L. J. Osborn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Assay:metagenomics· 2 Assay:bulk RNA-seq· 1 Organism:E. coli· 1 Organism:human· 1

Frequent Co-Authors

J. M. Brown· 5 shared J. Claesen· 4 shared B. DeLucia· 3 shared D. S. Allende· 3 shared W. Massey· 3 shared Z. Wang· 3 shared A. J. Horak· 2 shared A. Kadam· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersMicrobiology

J. M. Brown

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

M. Wang, L. J. Osborn, S. Jain, X. Meng, A. Weakley, J. Yan, W. Massey, V. Venkateshwari, A. J. Horak, R. Banerjee, D. S. Allende, R. Chan, A. Hajjar, A. Dimas, A. Zhao, , M. A. Fischbach

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.

bioRxiv · Jul 25, 2022Microbiology

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

R. N. Helsley, T. Miyata, A. Kadam, V. Venkateshwari, N. Sangwan, E. C. Huang, R. Banerjee, A. L. Brown, K. K. Fung, W. Massey, C. Neumann, O. Danny, L. J. Osborn, R. C. Schugar, M. R. McMullen, , J. M. Brown

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

bioRxiv · Dec 31, 2021Biochemistry

A 3D printable device allowing fast and reproducible longitudinal preparation of mouse intestines

B. DeLucia, S. Samorezov, M. T. Zangara, R. L. Markley, L. J. Osborn, K. B. Schultz, C. McDonald, J. Claesen

The paper introduces a 3D printable tool for quickly and consistently dissecting mouse intestines, reducing preparation time and improving reproducibility compared to traditional methods.

bioRxiv · Dec 1, 2021Pathology

A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis

L. J. Osborn, K. Schultz, W. Massey, B. DeLucia, I. Choucair, V. Varadharajan, K. Fung, A. J. Horak, D. Orabi, I. Nemet, L. E. Nagy, Z. Wang, D. S. Allende, N. Sangwan, A. M. Hajjar, , J. Claesen

bioRxiv · Sep 16, 2021Microbiology

Identification of essential genes for Escherichia coli aryl polyene biosynthesis and function in biofilm formation

I. Johnston, L. J. Osborn, R. L. Markley, E. A. McManus, A. Kadam, K. B. Schultz, N. Nagajothi, P. A. Ahern, J. M. Brown, J. Claesen

This study identifies essential genes for aryl polyene biosynthesis in E. coli and shows APEs enhance biofilm formation and oxidative stress resistance.

npj Biofilms and Microbiomes · Jul 2, 2021Peer-reviewedMicrobiology

A Novel Surgical Method for Continuous Intra-Portal Infusion of Gut Microbial Metabolites in Mice

D. Orabi, L. J. Osborn, K. Fung, F. Aucejo, I. Choucair, B. DeLucia, Z. Wang, J. Claesen, J. M. Brown

This paper introduces a novel surgical method for continuous portal vein infusion of gut microbial metabolites in mice, demonstrating its effectiveness in altering plasma and hepatic metabolite levels and gene expression.

bioRxiv · Oct 29, 2020Microbiology