Author

D. S. Allende

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

J. M. Brown· 5 shared W. Massey· 4 shared A. J. Horak· 3 shared L. J. Osborn· 3 shared R. Banerjee· 3 shared A. L. Brown· 2 shared L. E. Nagy· 2 shared N. Sangwan· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersMicrobiology

J. M. Brown

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

M. Wang, L. J. Osborn, S. Jain, X. Meng, A. Weakley, J. Yan, W. Massey, V. Venkateshwari, A. J. Horak, R. Banerjee, D. S. Allende, R. Chan, A. Hajjar, A. Dimas, A. Zhao, , M. A. Fischbach

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.

bioRxiv · Jul 25, 2022Microbiology

Membrane-Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose Homeostasis

W. Massey, V. Varadharajan, R. Banerjee, A. L. Brown, A. J. Horak, R. C. Hohe, E. R. Chan, C. Pan, R. Zhang, D. S. Allende, A. J. Lusis, J. M. Brown

This study shows that MBOAT7 in adipocytes regulates PI homeostasis and contributes to hyperinsulinemia and systemic insulin resistance in mice.

bioRxiv · May 19, 2022 · PreprintBiochemistry

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

R. N. Helsley, T. Miyata, A. Kadam, V. Venkateshwari, N. Sangwan, E. C. Huang, R. Banerjee, A. L. Brown, K. K. Fung, W. Massey, C. Neumann, O. Danny, L. J. Osborn, R. C. Schugar, M. R. McMullen, , J. M. Brown

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

bioRxiv · Dec 31, 2021Biochemistry

A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis

L. J. Osborn, K. Schultz, W. Massey, B. DeLucia, I. Choucair, V. Varadharajan, K. Fung, A. J. Horak, D. Orabi, I. Nemet, L. E. Nagy, Z. Wang, D. S. Allende, N. Sangwan, A. M. Hajjar, , J. Claesen

bioRxiv · Sep 16, 2021Microbiology

Cholangiocarcinoma presents a distinct myeloid-derived suppressor cell signature compared to other hepatobiliary cancers

D. Bayik, A. Lauko, G. A. Roversi, E. Serbinowski, L.-A. Acevedo-Moreno, C. Lanigan, M. Orujov, A. Lo, T. Alban, D. J. Silver, J. M. Brown, D. S. Allende, F. N. Aucejo, J. D. Lathia

The paper identifies a distinct myeloid-derived suppressor cell (MDSC) signature in cholangiocarcinoma (CCA) compared to other hepatobiliary cancers, linking MDSC levels to disease outcomes and potential therapeutic targets.

bioRxiv · Dec 11, 2019 · PreprintPathology