Author

G. Xing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Pharmacology & Toxicology· 1 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

J. K. Eaton· 2 shared K. Dave· 2 shared L. Furst· 2 shared M. J. Wawer· 2 shared P. Chatterji· 2 shared V. S. Viswanathan· 2 shared A. M. Patel· 1 shared B. He· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

J. K. Eaton

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine

P. Chatterji, G. Xing, L. Furst, K. Dave, Q. Zhou, D. V. LaBarbera, D. A. Thamm, J. K. Eaton, M. J. Wawer, V. S. Viswanathan

This study validates ferroptosis in canine cancer cells, showing similar responses to human cells, supporting dogs as a model for developing ferroptosis-based cancer therapies.

bioRxiv · Apr 28, 2024 · PreprintCancer Biology

The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer

J. K. Eaton, P. Chatterji, L. Furst, S. Basak, A. M. Patel, Y. Y. Sweat, L. L. Cai, K. Dave, R. A. Victoria, E. Pizzi, J. Noorbakhsh, G. Tian, J. A. S. Roth, J. Hynes, G. Xing, , V. S. Viswanathan

This study identifies GCL inhibition as a strategy to induce ferroptosis in cancer cells, introducing novel inhibitors with potent cellular activity.

bioRxiv · Apr 28, 2024 · PreprintCancer Biology

Shu complex is an ATPase that regulates Rad51 filaments in homologous recombination-directed DNA damage response.

H. Ling, S. S. H. Chu, V. K. Jha, G. Xing

This study characterizes the yeast Shu complex as an ATPase that binds and modifies Rad51 filaments to regulate homologous recombination and DNA damage response.

bioRxiv · Apr 22, 2024 · PreprintBiochemistry

Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens

W.-T. He, X. Hou, J. Zhao, J. Sun, H. He, W. Si, J. Wang, Z. Jiang, Z. Yan, G. Xing, M. Lu, M. A. Suchard, X. Ji, W. Gong, B. He, , S. Su

The paper characterizes the virome of 1725 game animals in China, identifying 71 mammalian viruses, 45 novel, and highlighting potential zoonotic risks.

bioRxiv · Nov 10, 2021 · PreprintZoology

Serine catabolism generates NADPH to support hepatic lipogenesis

Z. Zhang, T. TeSlaa, X. Xu, X. Zeng, L. Yang, G. Xing, G. Tesz, M. Clasquin, J. Rabinowitz

The paper shows that liver generates NADPH for lipogenesis through serine catabolism, distinct from adipose which uses glucose and the pentose phosphate pathway.

bioRxiv · May 22, 2021Biochemistry

Qualitative and quantitative bioanalytical methods validation of aristolochic acid DNA adducts and application in human formalin-fixed paraffin-embedded hepatocellular carcinoma tissues

X. Wang, J. Song, Y. Dong, L. Hu, X. Chen, F. Yang, H. Qi, x. qi, W. Wen, S. Chen, G. Xing, J. Ren

This paper validates a method to quantify aristolochic acid DNA adducts in human tissues and applies it to hepatocellular carcinoma samples, finding a low prevalence of adducts.

bioRxiv · Aug 20, 2020 · PreprintPharmacology & Toxicology