CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus
V. R. Graziano, M. M. Alfajaro, C. Schmitz, R. B. Filler, M. S. Strine, J. Wei, L. L. Hsieh, M. T. Baldridge, T. J. Nice, S. Lee, R. C. Orchard, C. B. Wilen
This study uses a Cd300lf conditional knockout mouse to show that CD300lf on tuft cells is essential for persistent MNoVCR6 infection, while myelomonocytic cells are major targets for non-persistent MNoVCW3, with STAT1 restricting its tropism.
bioRxiv · Aug 19, 2020Microbiology