J. Wei

Perturbational single-cell profiling of patient tumors defines lineage- and context-specific programs of innate immune resistance

The paper uses patient tumor samples to identify lineage- and context-specific mechanisms of innate immune resistance through perturbational single-cell RNA sequencing.

Spatially-resolved single-cell atlas of ascidian endostyle provides insights into the origin of vertebrate pharyngeal organs

The paper constructs a spatially-resolved single-cell atlas of the ascidian endostyle, identifying new cell types and evolutionary insights into vertebrate pharyngeal organs.

GTPase-activating protein ARAP1 regulates circular dorsal ruffles as a nutrient uptake mechanism in the Hep3B hepatocellular carcinoma cell line

This study shows that ARAP1 regulates circular dorsal ruffles in Hep3B cells, and its deletion reduces malignant potential, suggesting CDRs contribute to cancer development through nutrient uptake.

NS2B-D55E and NS2B-E65D Variations are Responsible for Differences in NS2B-NS3 Protease Activities Between Japanese Encephalitis Virus Genotype I and III in Fluorogenic Peptide Model

This study identifies NS2B-55 and NS2B-65 variations as responsible for differences in NS2B-NS3 protease activity between JEV genotype I and III using fluorogenic peptide assays.

A dipteran parasite regulates 20E synthesis and antibacterial activity of the host for development through inducing host nitric oxide production

This study shows that a dipteran parasite increases host nitric oxide production to regulate 20E synthesis and antibacterial activity, supporting its development.

A novel rotavirus reverse genetics platform supports flexible insertion of exogenous genes and enables rapid development of a high-throughput neutralization assay

This paper develops a rotavirus reverse genetics platform enabling exogenous gene insertion and a high-throughput neutralization assay to study immune responses.

Anti-PD-1-iRGD Peptide Conjugate Boosts Antitumor Efficacy via Engagement Augmentation and Penetration Enhancement of T cells

This paper develops a PD-1-iRGD conjugate that enhances antitumor efficacy by improving T cell engagement and penetration, and expands a unique population of CD8+ T cells in the tumor microenvironment.

Migratory herbivorous waterfowl track multiple resource waves during spring migration

This study shows East Asian herbivorous waterfowl use both seed and green waves during spring migration, with species-specific strategies depending on body size and location.

Identification of Circular Dorsal Ruffles as Signal Platforms for the AKT pathways in Glomerular Podocytes

The paper identifies circular dorsal ruffles as signal platforms for the AKT-mTORC1 pathway in glomerular podocytes, linking them to kidney function and potential therapeutic targets.

cpSRP54 and FtsH cooperate thylakoid membrane associated proteostasis during de-etiolation in Arabidopsis thaliana

The paper shows cpSRP54 and FtsH work together in thylakoid membrane protein quality control during de-etiolation in Arabidopsis, and provides a trackable marker for monitoring their activities.

An oligosaccharide analog exhibited antifungal activity by misleading cell wall organization via targeting PHR transglucosidases

This paper shows that a chitosan oligosaccharide analog disrupts fungal cell wall organization by targeting PHR transglucosidases, leading to antifungal activity and synergy with existing fungicides.

Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

This study identifies 4-vinylanisole as an aggregation pheromone that promotes sexual maturation synchrony in gregarious female locusts through a juvenile hormone/vitellogenin pathway.

Dynamic urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury.

This study identifies urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury, highlighting potential biomarkers for SAMS.

Biological characteristics of two mesenchymal stem cell lines isolated from the umbilical cord and adipose tissue of a neonatal common hippo (Hippopotamus amphibius)

This study isolates and characterizes two mesenchymal stem cell lines from a neonatal common hippo, showing their fibroblastoid morphology, normal karyotype, and stemness markers, with distinct differentiation potentials.

Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617

The paper develops and characterizes monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and its variants, including B.1.617.2 Delta.

HBV enveloped particle secretion is positively regulated by GRP78 through direct interaction with preS1

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

Extraction, purification and anti-TMV effects of α (β)-2,7,11-cembratriene-4,6-diol from tobacco leaves

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

New insights into the earlier evolutionary history of epiphytic macrolichens

The paper identifies a Jurassic fossil as an epiphytic macrolichen, suggesting macrolichen diversity predates the Cenozoic diversification of extant lineages.

No observable guide-RNA-independent off-target mutation induced by prime editor

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

Establishment and characterization of fibroblast cultures derived from a female common hippopotamus (Hippopotamus amphibius) skin biopsy

This study establishes and characterizes fibroblast cultures from a female common hippopotamus, confirming their origin and viability for genetic preservation.

Bacterial PxRdl2 dsRNA increased the insecticidal activities of GABAR-targeting compounds against Plutella xylostella

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

Aminoglycoside antibiotics inhibit mycobacteriophage infection

This study shows that certain aminoglycoside antibiotics inhibit mycobacteriophage infection while others do not, suggesting a mechanism involving the amino sugar group.

Mosquito defensins enhance Japanese encephalitis virus infection by facilitating virus adsorption and entry within mosquito

This study shows mosquito defensin enhances JEV infection by promoting virus adsorption and down-regulating an antiviral protein.

Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

This paper identifies CD300lf as the primary receptor for murine norovirus in vivo but shows it is not used by human norovirus.

Inhibition of the av integrin-TGF-b axis improves natural killer cell function against glioblastoma stem cells

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

Viral Architecture of SARS-CoV-2 with Post-Fusion Spike Revealed by Cryo-EM

The paper uses cryo-EM to reveal the post-fusion structure of SARS-CoV-2, showing the S protein in a state with S1 disassociated.

Individualized ctDNA Fingerprints to Monitor Treatment Response and Recurrence in Multiple Cancer Types

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

Discovery Of UFO Proteins: Human-Virus Chimeric Proteins Generated During Influenza Virus Infection

The paper identifies host-virus chimeric proteins, called UFOs, generated during influenza virus infection through the translation of viral 5UTRs using host transcripts.

Comprehensive analysis of potential immunotherapy genomic biomarkers in 1,000 Chinese patients with cancer

This study analyzes four genomic biomarkers in 1,000 Chinese cancer patients to assess their distribution and associations with cancer types and mutations.