Author

R. C. Orchard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

L. L. Hsieh· 2 shared M. T. Baldridge· 2 shared A. O. Kolawole· 1 shared C. B. Wilen· 1 shared C. Schmitz· 1 shared C. Wilen· 1 shared C. Wobus· 1 shared E. A. Kennedy· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

L. L. Hsieh

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2 papers

Recent·Most cited

CD300lf conditional knockout mouse reveals strain-specific cellular tropism for murine norovirus

V. R. Graziano, M. M. Alfajaro, C. Schmitz, R. B. Filler, M. S. Strine, J. Wei, L. L. Hsieh, M. T. Baldridge, T. J. Nice, S. Lee, R. C. Orchard, C. B. Wilen

This study uses a Cd300lf conditional knockout mouse to show that CD300lf on tuft cells is essential for persistent MNoVCR6 infection, while myelomonocytic cells are major targets for non-persistent MNoVCW3, with STAT1 restricting its tropism.

bioRxiv · Aug 19, 2020Microbiology

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

V. Graziano, F. C. Walker, E. A. Kennedy, J. Wei, K. Ettayebi, M. Simoes, R. Filler, E. Hassan, L. L. Hsieh, A. O. Kolawole, C. Wobus, L. C. Lindesmith, R. S. Baric, M. Estes, R. C. Orchard, , C. Wilen

This paper identifies CD300lf as the primary receptor for murine norovirus in vivo but shows it is not used by human norovirus.

PLOS Pathogens · Apr 6, 2020Peer-reviewedMicrobiology