D. Castellano

Non-hypermutator cancers access driver mutations through reversals in germline mutational bias

The paper shows non-hypermutator cancers adapt by reversing germline mutation bias, enabling access to driver mutations through altered mutation spectra.

Comprehensive Landscape of Non-muscle Invasive Bladder Cancer Tumour Microenvironment and Prognostic value of Cancer-Associated Myofibroblasts

The paper analyzes the tumor microenvironment of NMIBC, finding that cancer-associated myofibroblasts are prognostic markers for progression and recurrence.

Shifts in mutation bias promote mutators by altering the distribution of fitness effects

The paper shows that shifts in mutation bias can increase the probability of beneficial mutations, promoting the emergence of mutator strains.

Extraordinary selection on the human X chromosome associated with archaic admixture

The paper identifies X chromosome regions with strong selection in non-African populations, showing no Neanderthal ancestry, and links them to ancient selection events.

Detection of Domestication Signals through the Analysis of the Full Distribution of Fitness Effects

The paper simulates domestication processes to analyze fitness effect distributions and shows challenges in inferring beneficial selection and demographic history from site frequency spectra.

Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis.

This study characterizes plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastases, finding reduced EV numbers and increased PD-L1 in melanoma patients with brain metastases.

Impact of mutation rate and selection at linked sites on DNA variation across the genomes of humans and other homininae

The paper examines how mutation rate, recombination rate, and selection at linked sites influence DNA diversity across homininae genomes, showing their interactions with genetic drift.

Immunohistochemistry-based taxonomical classification of bladder cancer predicts response to neoadjuvant chemotherapy

This paper shows that immunohistochemical classification of bladder cancer tumors predicts response to neoadjuvant chemotherapy, with BASQ-like tumors showing higher likelihood of complete response.

Comparison of the full distribution of fitness effects of new amino acid mutations across great apes

The paper compares the distribution of fitness effects of new amino acid mutations across great apes and finds similar deleterious DFE shapes but varying negative selection strength related to population size and epistasis.

Viruses rule over adaptation in conserved human proteins

The paper shows that virus-interacting proteins, even when conserved across species, experience high adaptive evolution, with viruses driving over 75% of adaptation in the most conserved human proteins.

Nearly Neutral Evolution Across the Drosophila melanogaster Genome

The paper examines the relationship between effective population size and the proportion of neutral mutations in Drosophila melanogaster using polymorphism data from North American and African lines.