L. M. Weiss

A Toxoplasma gondii O-glycosyltransferase that modulates bradyzoite cyst wall rigidity is structurally and functionally distinct from host homologues

This study identifies and characterizes a Toxoplasma gondii O-glycosyltransferase, T.gondii-GalNAc-T3, revealing structural and functional differences from host homologues and identifying potential drug targets for parasitic diseases.

Microsporidia dressing up: the spore polaroplast transport through the polar tube and transformation into the sporoplasm membrane

This study investigates the formation of the sporoplasm membrane during microsporidia spore germination, revealing that the polaroplast transforms into the sporoplasm membrane via the polar tube.

Toxoplasma scavenges mammalian host organelles through usurpation of host ESCRT-III and Vps4

This study shows Toxoplasma uses host ESCRT-III and Vps4 to scavenge host organelles into its parasitophorous vacuole through proteins TgGRA14 and TgGRA64.

Dense granule protein, GRA64 interacts with host cell ESCRT proteins during Toxoplasma gondii infection

This study identifies GRA64, a Toxoplasma gondii dense granule protein that interacts with host ESCRT proteins, and shows its role in intracystic vesicle formation during chronic infection.

Toxoplasma gondii subverts the host ESCRT machinery for parasite uptake of host cytosolic proteins

This study identifies TgGRA14 as a parasite protein that recruits the host ESCRT machinery to facilitate uptake of host cytosolic proteins across the parasitophorous vacuole membrane.

Toxoplasma gondii PPM3C, a secreted protein phosphatase, affects parasitophorous vacuole effector export

This study identifies TgPPM3C, a secreted phosphatase in Toxoplasma gondii, and shows it regulates effector export and host c-Myc induction by modulating phosphorylation of proteins like GRA16.

Fat Tissue Regulates the Pathogenesis and Severity of Cardiomyopathy in Murine Chagas Disease

This study shows that fat tissue loss in mice infected with Trypanosoma cruzi worsens cardiac parasite load, inflammation, and severity of chronic Chagas cardiomyopathy.

In vitro characterization of protein effector export in the bradyzoite stage of Toxoplasma gondii

The paper investigates effector protein export in Toxoplasma gondii bradyzoites, showing that some effectors remain exported beyond early infection stages.