Author

O. I. Fregoso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. Sandoval· 2 shared D. Li· 2 shared A. Cimarelli· 1 shared A. D. Frankel· 1 shared A. Lopez· 1 shared A. Marson· 1 shared A. Molaro· 1 shared B. W. Newton· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

C. Sandoval

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

NSC95397 is a Novel HIV-1 Latency Reversing Agent

R. Nichols Doyle, V. Yang, Y. I. Kayode, R. Damoiseaux, H. E. Taylor, O. I. Fregoso

This study identifies NSC95397 as a novel HIV-1 latency reversing agent that synergizes with existing LRAs and targets previously unrecognized pathways.

bioRxiv · May 24, 2023Microbiology

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrest

C. Sandoval, K. Nisson, O. I. Fregoso

This study shows HIV-1 Vpr induces DNA damage and activates NF-κB through ATM-NEMO, independent of cell cycle arrest, enhancing viral transcription and replication.

bioRxiv · May 23, 2023Microbiology

Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19

M. Cariou, L. Picard, L. Gueguen, S. Jacquet, A. Cimarelli, O. I. Fregoso, A. Molaro, V. Navratil, L. Etienne

This paper identifies evolutionary adaptations in SARS-CoV-2 interacting proteins in bats and primates, revealing host-specific determinants of viral susceptibility and COVID-19 severity.

bioRxiv · Apr 7, 2022Evolutionary Biology

HIV Vpr modulates the host DNA damage response at two independent steps to damage DNA and repress double-strand DNA break repair

D. Li, A. Lopez, C. Sandoval, R. Nichols-Doyle, O. I. Fregoso

This study shows HIV Vpr modulates the host DNA damage response by inducing DNA damage and repressing double-strand break repair through two independent mechanisms.

mBio · Aug 25, 2020Peer-reviewedMicrobiology

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

J. R. Johnson, D. C. Crosby, J. F. Hultquist, D. Li, J. Marlett, J. Swann, R. Hüttenhain, E. Verschueren, T. L. Johnson, B. W. Newton, M. Shales, P. Beltrao, A. D. Frankel, A. Marson, O. I. Fregoso, , N. J. Krogan

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

bioRxiv · Jan 6, 2020Microbiology