Author

L. Gueguen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 7 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 6 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Assay:proteomics· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. Cimarelli· 3 shared L. Etienne· 3 shared L. Picard· 2 shared M. Semon· 2 shared A. Calteau· 1 shared A. Dubost· 1 shared A. G. Morante· 1 shared A. Legrand· 1 shared

Activity by Year

2016-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersEvolutionary Biology

A. Cimarelli

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Author profile →

8 papers

Recent·Most cited

Dollo parsimony overestimates ancestral gene content reconstructions

A. G. Morante, L. Gueguen, P. Natsidis, M. J. Telford, D. J. Richter

This study compares Dollo parsimony and maximum likelihood methods for ancestral gene content reconstruction, finding Dollo parsimony overestimates ancestral gene content, especially near the root of the tree.

bioRxiv · Nov 20, 2023Evolutionary Biology

The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC

A. Legrand, C. Dahoui, C. De La Myre Mory, C. Loyer, K. Noy, L. Guiguettaz, M. Pillon, M. Wcislo, L. Gueguen, A. Cimarelli, M. Mateo, F. Fiorini, E. Ricci, L. Etienne

This paper identifies SAMD9L as an HIV-1 restriction factor that inhibits viral and cellular translation through a Schlafen-like box, with implications for HIV/AIDS and genetic diseases.

bioRxiv · Jan 19, 2023Immunology

Distinct evolutionary trajectories of SARS-CoV-2 interacting proteins in bats and primates identify important host determinants of COVID-19

M. Cariou, L. Picard, L. Gueguen, S. Jacquet, A. Cimarelli, O. I. Fregoso, A. Molaro, V. Navratil, L. Etienne

This paper identifies evolutionary adaptations in SARS-CoV-2 interacting proteins in bats and primates, revealing host-specific determinants of viral susceptibility and COVID-19 severity.

bioRxiv · Apr 7, 2022Evolutionary Biology

Phenotypic innovation in one tooth induced concerted developmental evolution in another

M. Semon, L. Gueguen, K. Steklikova, M. Mouginot, M. Peltier, P. Veber, S. Pantalacci

The paper shows that independent evolution of one organ involves coordinated developmental changes in both organs, facilitated by developmental system drift.

bioRxiv · Apr 22, 2020 · PreprintEvolutionary Biology

A codon model for associating phenotypic traits with altered selective patterns of sequence evolution

K. Halabi, E. Levy Karin, L. Gueguen, I. Mayrose

This paper introduces TraitRELAX, a phylogenetic model that detects changes in selection intensity associated with phenotypic trait transitions, and applies it to primate and bacterial case studies.

bioRxiv · Mar 4, 2020Evolutionary Biology

DGINN, an automated and highly-flexible pipeline for the Detection of Genetic INNovations on protein-coding genes

L. Picard, Q. Ganivet, O. Allatif, A. Cimarelli, L. Gueguen, L. Etienne

DGINN automates the detection of genetic innovations and adaptive evolution in protein-coding genes using multiple methods and validates it on primate genes.

bioRxiv · Feb 25, 2020Evolutionary Biology

Accurate detection of convergent amino-acid evolution with PCOC

C. Rey, L. Gueguen, M. Semon, B. Boussau

The paper introduces PCOC, a method to detect convergent amino-acid evolution by identifying shifts in amino acid preferences rather than exact substitutions, showing improved performance on simulations and plant protein alignments.

bioRxiv · Apr 20, 2018Evolutionary Biology

Ancestral genome estimation reveals the history of ecological diversification in Agrobacterium.

F. Lassalle, R. Planel, S. Penel, D. Chapulliot, V. Barbe, A. Dubost, A. Calteau, D. Vallenet, D. Mornico, T. Bigot, L. Gueguen, L. Vial, D. Muller, V. Daubin, X. Nesme

The paper estimates the ancestral genome history of Agrobacterium biovar 1 to reveal how horizontal gene transfer contributed to ecological diversification.

bioRxiv · Jan 13, 2016Evolutionary Biology