Author

S. Myong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:benchmark study· 1

Frequent Co-Authors

J. Shorter· 2 shared T. Paul· 2 shared A. Aksimentiev· 1 shared A. Baum· 1 shared A. C. Murthy· 1 shared A. Chesi· 1 shared A. Garcia-Sastre· 1 shared A. Ghanbari Niaki· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersBiochemistry

J. Shorter

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

L. Guo, J. R. Mann, J. C. Mauna, K. E. Copley, H. Wang, J. D. Rubien, H. M. Odeh, J. Lin, B. L. Lee, L. Ganser, E. Robinson, K. M. Kim, A. C. Murthy, T. Paul, B. Portz, , J. Shorter

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.

bioRxiv · Sep 4, 2023Biochemistry

Switch-like Compaction of Poly(ADP-ribose) Upon Cation Binding

M. Badiee, A. L. Kenet, L. R. Ganser, T. Paul, S. Myong, A. K. Leung

This study shows PAR is stiffer than DNA/RNA and undergoes switch-like compaction in response to cation binding and protein interactions.

bioRxiv · Mar 11, 2023 · PreprintBiophysics

Benchmarking Molecular Dynamics Force Fields for All-Atom Simulations of Biological Condensates

K. Sarthak, D. N. Winogradoff, Y. Ge, S. Myong, A. Aksimentiev

This study benchmarks molecular dynamics force fields for simulating biological condensates, finding that combined protein and RNA force fields with a common water model best describe RNA-protein interactions and protein conformations.

bioRxiv · Feb 9, 2023Biophysics

Molecular determinants of Karyopherin-β2 chaperone and disaggregation activity

C. Fare, K. Rhine, A. Lam, S. Myong, J. Shorter

This study identifies the minimal functional domain of Kapβ2 required for preventing and reversing prion-like domain-mediated aggregation of disease-linked RNA-binding proteins.

bioRxiv · Sep 14, 2022 · PreprintBiochemistry

The Hrq1 helicase stimulates Pso2 translesion nuclease activity to promote DNA inter-strand crosslink repair

C. M. Rogers, C.-Y. Lee, S. Parkins, N. J. Buehler, S. Wenzel, F. Martinez-Marquez, Y. Takagi, S. Myong, M. L. Bochman

This study shows Hrq1 helicase enhances Pso2 nuclease activity to facilitate DNA inter-strand crosslink repair in yeast.

bioRxiv · Apr 21, 2020Biochemistry

mRNA structure determines specificity of a polyQ-driven phase separation

E. M. Langdon, Y. Qiu, A. Ghanbari Niaki, G. McLaughlin, C. Weidmann, T. Gerbich, J. A. Smith, J. M. Crutchley, C. M. Termini, K. M. Weeks, S. Myong, A. Gladfelter

The paper shows that mRNA secondary structures determine RNA-RNA interactions that influence phase separation and compartment identity.

bioRxiv · Mar 7, 2018Cell Biology

Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression

S. Doganay, M. Y. Lee, A. Baum, J. Peh, S.-Y. Hwang, J.-Y. Yoo, P. J. Hergenrother, A. Garcia-Sastre, S. Myong, T. Ha

The paper identifies early antiviral gene expression patterns and shows that RLRs drive stochastic IFNB1 expression independent of IFN.

bioRxiv · Aug 31, 2017Biophysics