Author

L. Rutten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:electronic health records· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Akiva· 4 shared N. Sommerdijk· 4 shared D. Daviran· 2 shared D. H. Barouch· 2 shared E. J. Snijder· 2 shared E. Macias-Sanchez· 2 shared F. Wegmann· 2 shared H. Schuitemaker· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersBiochemistry

A. Akiva

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Author profile →

6 papers

Recent·Most cited

Unravelling the relationship between isolated bone matrix vesicles and forming mineral at the nanometer scale

M. A. Eufrasio Cruz, L. Rutten, M. Martens, O. Arntz, F. van de Loo, E. Macias Sanchez, A. Akiva, P. Ciancaglini, A. P. Ramos, N. Sommerdijk

This study investigates the role of matrix vesicles in bone mineralization using cryoTEM and bulk analysis, revealing that mineralization is primarily driven by phosphatase activity with non-vesicular components playing a secondary role.

bioRxiv · May 9, 2023 · PreprintBiophysics

A Cryo-to-Liquid Phase Correlative Light Electron Microscopy Workflow for the Visualization of Biological Processes in Graphene Liquid Cells

L. Rutten, B. Joosten, J. M. Schaart, M. d. Beer, R. Roverts, S. Graber, W. Jahnen-Dechent, A. Akiva, E. Macias-Sanchez, N. Sommerdijk

This paper introduces a cryo-to-liquid phase correlative light/electron microscopy workflow to overcome limitations of graphene liquid cells and enables imaging of biological processes.

bioRxiv · May 8, 2023Biochemistry

A 3D cell-free bone model shows collagen mineralization is driven and controlled by the matrix

R. H. M. Van der Meijden, D. Daviran, L. Rutten, F. Walboomers, E. Macias-Sanchez, N. Sommerdijk, A. Akiva

This study demonstrates that collagen mineralization in bone is driven by the extracellular matrix, not cellular activity, using a 3D cell-free bone model.

bioRxiv · Oct 24, 2022Biochemistry

Precise targeting for 3D cryo-correlative light and electron microscopy volume imaging of tissues using a FinderTOP

M. de Beer, D. Daviran, R. Roverts, L. Rutten, e. M. Sanchez, J. Metz, n. Sommerdijk, A. Akiva

This paper introduces a method for 3D cryo-correlative light and electron microscopy of tissues using a FinderTOP pattern for precise targeting.

bioRxiv · Jul 31, 2022Cell Biology

Ad26.COV2.S-elicited immunity protects against G614 spike variant SARS-CoV-2 infection in Syrian hamsters and does not enhance respiratory disease in challenged animals with breakthrough infection after sub-optimal vaccine dosing

J. E. M. van der Lubbe, S. K. Rosendahl Huber, A. Vijayan, L. Dekking, E. van Huizen, J. Vreugdenhil, Y. Choi, M. R. M. Baert, K. Feddes-de Boer, A. Izquierdo Gil, M. van Heerden, T. J. Dalebout, S. K. Myeni, M. Kikkert, E. J. Snijder, , F. Wegmann

This study shows that a single dose of Ad26.COV2.S vaccine protects Syrian hamsters from G614 SARS-CoV-2 infection and prevents VAERD even with suboptimal immunity.

bioRxiv · Jan 8, 2021 · PreprintImmunology

Ad26-vector based COVID-19 vaccine encoding a prefusion stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

R. Bos, L. Rutten, J. E. M. van der Lubbe, M. J. G. Bakkers, G. Hardenberg, F. Wegmann, D. Zuijdgeest, A. H. de Wilde, A. Koornneef, A. Verwilligen, D. van Manen, T. Kwaks, R. Vogels, T. J. Dalebout, S. K. Myeni, , H. Schuitemaker

This paper evaluates a prefusion-stabilized SARS-CoV-2 Spike protein vaccine candidate, Ad26.COV2.S, showing potent neutralizing and Th1-polarized immune responses in mice.

bioRxiv · Jul 30, 2020Immunology