Author

I. Tenvooren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 6 Assay:flow cytometry· 5 Organism:human· 5 Research Focus:cell signaling & trafficking· 4 Organism:mouse· 4 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3

Frequent Co-Authors

M. H. Spitzer· 7 shared D. M. Marquez· 5 shared E. E. McCarthy· 2 shared J. L. Yee· 2 shared K. M. Ansel· 2 shared M. F. Krummel· 2 shared R. DeBarge· 2 shared T. L. H. Okholm· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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7 shared papersImmunology

M. H. Spitzer

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7 papers

Recent·Most cited

A mass cytometry approach to track the evolution of T cell responses during infection and immunotherapy by paired T cell receptor repertoire and T cell differentiation state analysis

J. G. Castillo, R. DeBarge, A. Mende, I. Tenvooren, D. M. Marquez, A. Straub, D. H. Busch, M. H. Spitzer, M. DuPage

The paper develops a mass cytometry method to track T cell receptor repertoires and differentiation states during infection and immunotherapy, showing how antigen recognition influences T cell responses.

bioRxiv · Jan 11, 2024 · PreprintImmunology

Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted by metastasis

M. K. Rahim, T. L. H. Okholm, K. B. Jones, E. E. McCarthy, C. C. Liu, J. L. Yee, S. J. Tamaki, D. M. Marquez, I. Tenvooren, K. Wai, A. Cheung, B. R. Davidson, V. Johri, B. Samad, W. E. O'Gorman, , M. H. Spitzer

The paper examines CD8+ T cell responses in human lymph nodes during cancer immunotherapy and finds that metastasis disrupts these responses.

bioRxiv · Nov 8, 2022 · PreprintImmunology

T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFa Inflammation.

N. W. Cho, S. M. Guldberg, B. Y. Nabet, J. Z. Yu, E. J. Kim, K. J. Hiam-Galvez, J. L. Yee, R. DeBarge, I. Tenvooren, N. A. Ashitey, F. Lynce, D. A. Dillon, J. M. Rosenbluth, M. H. Spitzer

The paper identifies a novel mechanism of ICI resistance where T cells drive inflammatory resistance via IL-1 and TNF in tumors, with implications for therapy.

bioRxiv · Sep 20, 2022Immunology

A conserved immune trajectory of recovery in hospitalized COVID-19 patients

T. L. H. Okholm, C. E. Burnett, I. Tenvooren, D. M. Marquez, S. Tamaki, P. M. Sandoval, The UCSF COMET Consortium, C. S. Calfee, C. M. Hendrickson, K. N. Kangelaris, C. R. Langelier, M. F. Krummel, P. G. Woodruff, D. J. Erle, K. M. Ansel, M. H. Spitzer

The paper identifies a conserved immune recovery trajectory in hospitalized COVID-19 patients through longitudinal mass cytometry analysis, linking immune processes to clinical outcomes.

bioRxiv · Mar 15, 2022 · PreprintImmunology

Distinct cellular immune signatures in acute Zika virus infection are associated withhigh or low persisting neutralizing antibody titers

E. E. McCarthy, P. M. Odorizzi, E. Lutz, C. P. Smullin, I. Tenvooren, M. Stone, G. Simmons, P. W. Hunt, M. E. Feeney, P. J. Norris, M. P. Busch, M. H. Spitzer, R. L. Rutishauser

The paper uses mass cytometry to identify immune cell signatures in acute ZIKV infection that predict high or low neutralizing antibody titers 6 months post-infection.

bioRxiv · May 27, 2021 · PreprintImmunology

Type 2 innate immunity regulates hair follicle homeostasis to control Demodex pathosymbionts

R. R. Ricardo-Gonzalez, M. E. Kotas, I. Tenvooren, D. M. Marquez, M. S. Fassett, J. Lee, S. G. Daniel, K. Bittinger, R. E. Diaz, J. S. Fraser, K. M. Ansel, M. H. Spitzer, H.-E. Liang, R. M. Locksley

This study shows that type 2 innate immunity, via ILC2s, regulates hair follicle homeostasis and maintains commensal Demodex mite colonization.

bioRxiv · Mar 29, 2021 · PreprintImmunology

Single-cell metabolic dynamics of early activated CD8 T cells during the primary immune response to infection

L. S. Levine, K. J. Hiam, D. M. Marquez, I. Tenvooren, D. C. Contreras, J. C. Rathmell, M. H. Spitzer

The paper examines metabolic dynamics in early activated CD8 T cells during the primary immune response, identifying a transient state with maximal glycolytic and oxidative metabolic activity.

bioRxiv · Jan 21, 2020 · PreprintImmunology