Author

L. Sedlackova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

B. Carroll· 2 shared G. Nelson· 2 shared V. I. Korolchuk· 2 shared A. Acharjee· 1 shared A. Byron· 1 shared A. Sanz· 1 shared A. Wirth· 1 shared B. Vanhaesebroeck· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

B. Carroll

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2 papers

Recent·Most cited

mTORC1 activity is supported by spatial association with focal adhesions

Y. Rabanal-Ruiz, A. Byron, A. Wirth, R. R. Madsen, L. Sedlackova, G. Hewitt, G. Nelson, J. Stingele, R. Faessler, B. Vanhaesebroeck, O. Maddocks, E. Ponimaskin, B. Carroll, V. I. Korolchuk

This study shows that mTORC1 activation by growth factors and amino acids requires its spatial association with focal adhesions, independent of lysosomal distribution.

bioRxiv · Nov 20, 2020Cell Biology

Autophagy promotes cell and organismal survival by maintaining NAD(H) pools

L. Sedlackova, E. G. Otten, F. Scialo, D. Shapira, T. Kataura, B. Carroll, E. Seranova, Y. Rabanal Ruiz, G. Kelly, R. Stefanatos, G. Nelson, F. Urselli, A. Acharjee, N. S. Kenneth, S. A. Trushin, , V. I. Korolchuk

This study identifies autophagy's role in maintaining NAD(H) pools, showing that NAD(H) depletion leads to cell death and that NAD(H) supplementation can reverse this effect in autophagy-deficient models.

bioRxiv · Jan 31, 2020 · PreprintCell Biology