G. Nelson

Activation of PIEZO1 Inhibits Kidney Cystogenesis

This study shows that activating PIEZO1 reduces cyst formation in kidney cells and ex vivo models, suggesting it could be a therapeutic target for ADPKD.

Detection of a geminate photoproduct of bovine cytochrome c oxidase by time-resolved serial femtosecond crystallography

The paper detects a geminate photoproduct of bovine cytochrome c oxidase using time-resolved serial femtosecond crystallography, revealing the ligand dissociation trajectory and protein dynamics.

A recombinant ACE2 Triple Decoy that traps and neutralizes SARS-CoV-2 shows enhanced affinity for highly transmissible SARS-CoV-2 variants

The paper develops an ACE2 Triple Decoy that maintains high affinity for SARS-CoV-2 variants and shows enhanced affinity for specific mutations.

Molecular dynamic simulation reveals E484K mutation enhances spike RBD-ACE2 affinity and the combination of E484K, K417N and N501Y mutations (501Y.V2 variant) induces conformational change greater than N501Y mutant alone, potentially resulting in an escape mutant

This study uses molecular dynamics simulations to show that the E484K mutation increases spike RBD-ACE2 affinity and that the combination of E484K, K417N, and N501Y mutations causes greater conformational changes, potentially leading to antibody escape.

Millisecond-scale molecular dynamics simulation of spike RBD structure reveals evolutionary adaption of SARS-CoV-2 to stably bind ACE2

The paper uses molecular dynamics simulations to study SARS-CoV-2 spike RBD interactions with ACE2, revealing an optimized binding conformation and potential targets for therapeutics.

Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL

The paper directly observes fast ligand binding in a biomedically relevant enzyme using MHz X-ray pulses at the European XFEL.

mTORC1 activity is supported by spatial association with focal adhesions

This study shows that mTORC1 activation by growth factors and amino acids requires its spatial association with focal adhesions, independent of lysosomal distribution.

Identification of root rot resistance QTLs in pea using Fusarium solani f. sp. pisi-responsive differentially expressed genes

This study identifies QTLs associated with resistance to Fusarium solani f. sp. pisi in pea using SNPs from differentially expressed genes, finding one major QTL on chromosome V and four additional QTLs.

Autophagy promotes cell and organismal survival by maintaining NAD(H) pools

This study identifies autophagy's role in maintaining NAD(H) pools, showing that NAD(H) depletion leads to cell death and that NAD(H) supplementation can reverse this effect in autophagy-deficient models.

The association between caesarean section delivery and later life obesity in 21-24 year olds in an Urban South African birth cohort

This study examines the link between caesarean section delivery and obesity in young adults in a South African cohort, finding a significant association after adjusting for several confounders.

Enzyme Intermediates Captured "on-the-fly" by Mix-and-Inject Serial Crystallography

This paper demonstrates a method to capture enzyme reactions in real-time using mix-and-inject serial crystallography, revealing antibiotic cleavage and kinetic transitions in Mycobacterium tuberculosis β-lactamase.

Fast and Flexible GPU Accelerated Binding Free Energy Calculations within the AMBER Molecular Dynamics Package

The paper introduces a GPU-accelerated implementation of thermodynamic integration in AMBER for faster and more efficient alchemical free energy calculations.