Author

V. I. Korolchuk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

B. Carroll· 3 shared G. Nelson· 2 shared L. Sedlackova· 2 shared T. Kataura· 2 shared A. Acharjee· 1 shared A. Byron· 1 shared A. J. Kowaltowski· 1 shared A. Kopach· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

B. Carroll

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Mitochondrial Sodium/Calcium Exchanger (NCLX) Regulates Basal and Starvation-Induced Autophagy Through Calcium Signaling

V. de Miranda Ramos, J. D. Serna, E. A. Vilas-Boas, J. V. Cabral-Costa, F. M. da Cunha, T. Kataura, V. I. Korolchuk, A. J. Kowaltowski

This study shows that NCLX regulates autophagy via calcium signaling, with NCLX knockdown impairing basal and starvation-induced autophagy.

bioRxiv · Mar 17, 2023 · PreprintCell Biology

Microsporidian obligate intracellular parasites subvert autophagy of infected mammalian host cells to promote their own growth

J. Panek, K. M. Sendra, H. Glenwright, G. Kosta, V. I. Korolchuk, R. P. Hirt

This study shows that Microsporidia manipulate host autophagy in mammalian cells to enhance their growth instead of being degraded.

bioRxiv · Aug 15, 2022Microbiology

mTORC1 activity is supported by spatial association with focal adhesions

Y. Rabanal-Ruiz, A. Byron, A. Wirth, R. R. Madsen, L. Sedlackova, G. Hewitt, G. Nelson, J. Stingele, R. Faessler, B. Vanhaesebroeck, O. Maddocks, E. Ponimaskin, B. Carroll, V. I. Korolchuk

This study shows that mTORC1 activation by growth factors and amino acids requires its spatial association with focal adhesions, independent of lysosomal distribution.

bioRxiv · Nov 20, 2020Cell Biology

G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules

M. T. Prentzell, U. Rehbein, M. Cadena Sandoval, A.-S. De Meulemeester, R. Baumeister, L. Brohee, B. Berdel, M. Bockwoldt, B. Carroll, A. von Deimling, C. Demetriades, G. Figlia, A. M. Heberle, I. Heiland, B. Holzwarth, , K. Thedieck

This paper shows G3BP1 anchors the TSC complex to lysosomes to suppress mTORC1 signaling without stress granules, and inhibits mTORC1-driven cancer and neuronal issues.

bioRxiv · Apr 16, 2020Cell Biology

Autophagy promotes cell and organismal survival by maintaining NAD(H) pools

L. Sedlackova, E. G. Otten, F. Scialo, D. Shapira, T. Kataura, B. Carroll, E. Seranova, Y. Rabanal Ruiz, G. Kelly, R. Stefanatos, G. Nelson, F. Urselli, A. Acharjee, N. S. Kenneth, S. A. Trushin, , V. I. Korolchuk

This study identifies autophagy's role in maintaining NAD(H) pools, showing that NAD(H) depletion leads to cell death and that NAD(H) supplementation can reverse this effect in autophagy-deficient models.

bioRxiv · Jan 31, 2020 · PreprintCell Biology

mTORC1-Plin3 pathway is essential to activate lipophagy and protects against hepatosteatosis.

M. Garcia-Macia, A. Santos-Ledo, J. Leslie, H. Paish, A. Watson, L. Borthwick, J. Mann, F. Oakley, V. I. Korolchuk, D. A. Mann

This study identifies the mTORC1-Plin3 pathway as essential for lipophagy, which protects against hepatosteatosis by promoting lipid droplet degradation.

bioRxiv · Oct 21, 2019Cell Biology