Author

O. Maddocks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Byron· 1 shared A. H. Uribe· 1 shared A. Wirth· 1 shared B. Carroll· 1 shared B. Cong· 1 shared B. Vanhaesebroeck· 1 shared E. Ponimaskin· 1 shared E. Stamou· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCell Biology

A. Byron

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2 papers

Recent·Most cited

Colon Cancer Cells Evade Drug Action by Enhancing Drug Metabolism

B. Cong, T. Thakur, A. H. Uribe, E. Stamou, S. Gopinath, O. Maddocks, R. Cagan

The paper identifies glucuronidation pathway upregulation as a mechanism by which colon cancer cells develop resistance to trametinib, showing that inhibiting this pathway can reverse resistance in both Drosophila and mouse models.

bioRxiv · Dec 21, 2023Cancer Biology

mTORC1 activity is supported by spatial association with focal adhesions

Y. Rabanal-Ruiz, A. Byron, A. Wirth, R. R. Madsen, L. Sedlackova, G. Hewitt, G. Nelson, J. Stingele, R. Faessler, B. Vanhaesebroeck, O. Maddocks, E. Ponimaskin, B. Carroll, V. I. Korolchuk

This study shows that mTORC1 activation by growth factors and amino acids requires its spatial association with focal adhesions, independent of lysosomal distribution.

bioRxiv · Nov 20, 2020Cell Biology