A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
X. Wang, A. Hu, X. Chen, Y. Zhang, F. Yu, S. Yue, A. Li, J. Zhang, Z. Pan, Y. Yang, Y. Lin, L. Gao, J. Zhou, J. Zhao, F. Li, , L. Ye
This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.
bioRxiv · Nov 29, 2021Immunology