S. Yue

MICLEAR: Intelligent Molecular Cytology for Intraoperative Margin Assessment of Pancreatic Ductal Adenocarcinoma

MICLEAR uses Raman imaging and machine learning to assess PDAC surgical margins with high accuracy and speed.

Accurate and Rapid Detection of Peritoneal Metastasis from Gastric Cancer by AI-assisted Stimulated Raman Cytology

This paper develops an AI-assisted stimulated Raman cytology method to detect peritoneal metastasis in gastric cancer with high accuracy and speed.

VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

Flow-induced mechanical coupling between perinuclear actin cap and nucleus governs spatiotemporal regulation of YAP transport

This study investigates how flow-induced mechanical forces regulate YAP nucleocytoplasmic transport through actin cap formation and nuclear stiffness changes, revealing a unified mechanism linking mechanical stimulation to transcriptional regulation.

Excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics

This study investigates the excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics using transient absorption and fluorescence spectroscopy, revealing differences in dynamics across mutants and potential applications in bioimaging.

How the insect central complex could coordinate multimodal navigation

This paper tests a computational model's ability to generalize from visual to olfactory navigation in insects and shows how a neural mechanism enables robust navigation across sensory inputs.

A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD

This study identifies a potent human monoclonal antibody, 35B5, that neutralizes SARS-CoV-2 and its variants by targeting a conserved epitope on the RBD, offering a potential therapeutic and vaccine design strategy.

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

An Assistive Computer Vision Tool to Automatically Detect Changes in Fish Behavior In Response to Ambient Odor

This paper develops a computer vision tool to automate detection of zebrafish behavioral changes in response to ambient odor using deep learning with minimal expert supervision.

A Decentralised Neural Model Explaining Optimal Integration of Navigational Strategies in Insects

This paper presents a neural model explaining how insects integrate navigational strategies by coordinating different brain regions to process and combine visual cues.

AVDM: Angular Velocity Decoding Model Accounting for Visually Guided Flight Behaviours of the Bee

The paper introduces an angular velocity decoding model for honeybee flight behaviors, showing independence from spatial frequency and contrast, and validating it through simulations and behavioral experiments.

Cell type-specific role of lamin-B1 and its inflammation-driven reduction in organ building and aging

This study shows lamin-B1 in thymic epithelial cells is reduced with aging due to inflammation, leading to thymus degeneration and impaired function.