Author

L. Vandekerckhove

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Cole· 2 shared L. Lambrechts· 2 shared M. Pardons· 2 shared S. Palmer· 2 shared Y. Noppe· 2 shared A. van der Ven· 1 shared A. Zhernakova· 1 shared B. Autran· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersMicrobiology

B. Cole

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A truncated HIV Tat demonstrates potent and specific latency reversal activity

E. Van Gulck, M. Pardons, E. Nijs, N. Verheyen, K. Dockx, C. Van Den Eynde, E. Battivelli, J. Vega, E. Florence, B. Autran, N. Archin, D. M. Margolis, C. Katlama, C. Hamimi, I. Van Den Wyngaert, , D. Boden

The paper demonstrates that a truncated HIV Tat protein and mRNA can reactivate HIV-1 in latently infected T-cells as effectively as Phorbol 12-Myristate 13-Acetate without T-cell activation or significant transcriptome changes.

bioRxiv · Mar 2, 2023 · PreprintCell Biology

HIV-linked gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV

Y. Zhang, S. Andreu-Sanchez, N. Vadaq, D. Wang, V. Matzaraki, W. van der Heijden, R. Gacesa, R. K. Weersma, A. Zhernakova, L. Vandekerckhove, Q. de Mast, L. A. Joosten, M. Netea, A. van der Ven, J. Fu

This study links HIV-associated gut dysbiosis to cytokine production capacity in ART-suppressed PLHIV, identifying specific microbial strains associated with immune markers.

bioRxiv · Apr 21, 2022 · PreprintMicrobiology

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

B. Cole, L. Lambrechts, P. Gantner, Y. Noppe, N. Bonine, W. Witkowski, L. H. Chen, S. Palmer, J. I. Mullins, N. Chomont, M. Pardons, L. Vandekerckhove

This study uses STIP-Seq to analyze HIV-1 reservoirs and identifies proviral features and cellular sources contributing to plasma viremia in ART-suppressed individuals.

bioRxiv · Feb 15, 2021Microbiology

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption

B. Cole, L. Lambrechts, Z. Boyer, Y. Noppe, M.-A. De Scheerder, J.-S. Eden, B. Vrancken, T. Schlub, L. M. Frenkel, S. McLaughlin, S. Palmer, L. Vandekerckhove

This study characterizes HIV-1 reservoirs in four individuals during treatment interruption, identifying proviruses linked to plasma viremia and showing their role in viral rebound.

bioRxiv · Feb 4, 2021Microbiology