Author

L. A. Joosten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. G. Netea· 2 shared M. Netea· 2 shared N. Vadaq· 2 shared Q. de Mast· 2 shared A. Dumaine· 1 shared A. Eugster· 1 shared A. J. van der Ven· 1 shared A. van der Ven· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

M. G. Netea

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow

S. J. Sun, R. Aguirre-Gamboa, C. J. de Bree, J. Sanz, A. Dumaine, L. A. Joosten, M. Divangahi, M. Netea, L. B. Barreiro

This study shows BCG vaccination changes gene expression and chromatin accessibility in human bone marrow progenitor cells, linking these changes to innate immune responses.

bioRxiv · Nov 28, 2023 · PreprintImmunology

Differences in the inflammatory proteome of East African and Western European adults and associations with environmental and dietary factors

G. S. Temba, N. Vadaq, V. Kullaya, T. Pecht, P. Lionetti, D. Cavalieri, J. Schultze, R. Kavishe, L. A. Joosten, A. J. van der Ven, B. T. Mmbaga, M. G. Netea, Q. de Mast

The paper compares the inflammatory proteome of Tanzanian and Dutch adults, finding a pro-inflammatory phenotype in Tanzanians linked to dietary factors and metabolic regulators.

bioRxiv · Aug 23, 2022Immunology

HIV-linked gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV

Y. Zhang, S. Andreu-Sanchez, N. Vadaq, D. Wang, V. Matzaraki, W. van der Heijden, R. Gacesa, R. K. Weersma, A. Zhernakova, L. Vandekerckhove, Q. de Mast, L. A. Joosten, M. Netea, A. van der Ven, J. Fu

This study links HIV-associated gut dysbiosis to cytokine production capacity in ART-suppressed PLHIV, identifying specific microbial strains associated with immune markers.

bioRxiv · Apr 21, 2022 · PreprintMicrobiology

Heme induces innate immunity memory

E. Jentho, B. Novakovic, C. C. Ruiz-Moreno, I. Kourtzelis, R. Martins, T. Chavakis, M. P. Soares, L. Kalafati, J. Guerra, F. Roestel, P. Bohm, M. Godmann, T. Grinenko, A. Eugster, M. Beretta, , S. Weis

This study shows heme induces trained immunity in human and murine cells, leading to long-term protection against bacterial sepsis through epigenetic and transcriptional changes.

bioRxiv · Dec 12, 2019 · PreprintImmunology