S. Palmer

The immunosuppressive Tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells

This study shows that the TB-associated microenvironment suppresses HIV-1 replication and promotes latency in CD4+ T cells from HIV-1 patients.

Thymic epithelial cell fate and potency in early organogenesis assessed by single cell transcriptional and functional analysis.

The paper uses single-cell RNA sequencing to analyze thymic epithelial cell fate and potency in early mouse thymus development, revealing sublineage-primed progenitors and functional bipotency changes.

Combined multidimensional single-cell protein and RNA profiling dissects the cellular and functional heterogeneity of thymic epithelial cells

The paper uses combined single-cell protein and RNA profiling to identify and characterize novel subpopulations of thymic epithelial cells and their functional roles.

Dynamic evolution of MLKL in primate and poxvirus genomes indicates necroptosis is a critical, not auxiliary, countermeasure during infection

This study shows MLKL is a critical, not auxiliary, host defense against infection, with evidence of rapid evolution, viral homologs, and cytokine induction.

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

This study uses STIP-Seq to analyze HIV-1 reservoirs and identifies proviral features and cellular sources contributing to plasma viremia in ART-suppressed individuals.

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruption

This study characterizes HIV-1 reservoirs in four individuals during treatment interruption, identifying proviruses linked to plasma viremia and showing their role in viral rebound.

The Atlas of the In Vivo HIV CD4 T Cell Reservoir

The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.