hnRNPUL1 ensures efficient Integrator-mediated cleavage of snRNAs and is mutated in amyotrophic lateral sclerosis
Ivaylo D Yonchev, Carmen V. Apostol, Llywelyn Griffith, Ang Li, Larissa Butler, Helen Patrick, Elisa Aguilar-Martínez, Ashleigh G. R. Whelan, Caroline A. Evans, Mark J. Dickman, Johnathan Cooper‐Knock, Pamela J. Shaw, Steven West, Ivana Barbaric, Ian M. Sudbery, Stuart A. Wilson
This study identifies hnRNPUL1's role in Integrator-mediated snRNA cleavage and links its mutations to amyotrophic lateral sclerosis.
bioRxiv · Jul 22, 2023 · PreprintMolecular Biology