Author

Lauren Escobedo

University of Maryland, Baltimore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Yilun SuniD· 3 shared Yves G. PommieriD· 2 shared Anish ThomasiD· 1 shared Anjali DhalliD· 1 shared Anthony K. L. LeungiD· 1 shared Augustin LunaiD· 1 shared Christophe E. RedoniD· 1 shared Dahun UmiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersCancer Biology

Yilun SunORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Sensitizing tumor response to topoisomerase I antibody drug conjugate by selective CDK7 inhibition

Hyerim Jung, Yoonji Lee, DongHoon Yu, Yeejin Jeon, Hwankyu Kang, Dahun Um, Mooyoung Seo, Dongsik Park, Jeongjun Kim, Seung-Joo Lee, Jaeseung Kim, Lauren Escobedo, Yilun Sun, Anish Thomas, Kiyean Nam, Tae-Kyung Kim

This study shows that Q901, a CDK7 inhibitor, enhances cancer susceptibility to TOP1 inhibitors by stabilizing TOP1-DPCs and suppressing DNA repair pathways.

Science Advances · Sep 30, 2026Peer-reviewedCancer Biology

Bimodal genomic approach predicting Semaphorin 7A (SEMA7A) as prognostic biomarker in adrenocortical carcinoma

Anjali Dhall, Daiki Taniyama, Fathi Elloumi, Augustin Luna, Sudhir Varma, Suresh S. Kumar, Lauren Escobedo, Yilun Sun, Mirit I. Aladjem, Christophe E. Redon, Nitin Roper, William C. Reinhold, Jaydira Del Rivero, Yves G. Pommier

This paper identifies SEMA7A as a prognostic biomarker in adrenocortical carcinoma using transcriptome data from TCGA and NCI samples, showing its association with poor prognosis and specific signaling pathways.

Cancers · Jun 21, 2025Peer-reviewedCancer Biology

Flap endonuclease 1 repairs DNA-protein crosslinks via ADP-ribosylation

Yilun Sun, Lisa M. Miller Jenkins, Lara H. El Touny, Linying Zhu, Xi Yang, Ukhyun Jo, Lauren Escobedo, Tapan Kumar Maity, Liton Kumar Saha, Isabel R. Uribe, Sourav Saha, Shunichi Takeda, Anthony K. L. Leung, Ken Chih-Chien Cheng, Yves G. Pommier

This study identifies FA-induced DNA-protein crosslinks (DPCs) and discovers that FEN1 repairs them via PARylation, revealing a novel PARP1-FEN1 pathway for DPC repair.

Science Advances · Jan 10, 2025Peer-reviewedMolecular Biology