Federico Ansaloni

Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glia responses

The paper uses single nuclei RNAseq to identify distinct glial gene expression patterns in MS patients, revealing subgroup-specific pathological processes and suggesting precision medicine approaches.

Paternal starvation affects metabolic gene expression during zebrafish offspring development and life-long fitness

This study shows that paternal starvation in zebrafish affects offspring metabolism and fitness, with lasting impacts on gene expression and development.

Internal Ribosome Entry Sites act as Effector Domain in linear and circular antisense long non-coding SINEUP RNAs

This study identifies SINEUP RNAs with Internal Ribosomal Entry Site (IRES) sequences as effector domains, enhancing translation of target mRNAs through both linear and circular transcripts.

Pgbd5 impacts neuronal differentiation and double strand breaks signaling in the developing cortex

This study shows Pgbd5 is essential for neuronal differentiation and radial migration in mouse corticogenesis, with effects on DNA double-strand breaks and gene expression.

The miR-430 locus with extreme promoter density is a transcription body organizer, which facilitates long range regulation in zygotic genome activation

The paper identifies a high-density miR-430 promoter cluster that forms a transcription body, enabling early gene activation during the minor wave of zygotic genome activation in zebrafish.

Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain

The paper identifies LINE retrotransposons and long non-coding RNAs in octopus brains, suggesting their role in cognitive evolution through germline and somatic activity.

Transposable Element activation promotes neurodegeneration in a Drosophila model of Huntington's disease

This study shows that transposable element activation contributes to neurodegeneration in a Drosophila Huntington's disease model and can be inhibited to rescue neurodegeneration and extend lifespan.