Remo Sanges

Foxg1 regulates translation of neocortical neuronal genes, including the main NMDA receptor subunit gene, Grin1.

The paper shows Foxg1 enhances Grin1 mRNA translation in neocortical neurons by interacting with translation factors and regulating ribosome engagement, impacting NMDA receptor function.

Paternal starvation affects metabolic gene expression during zebrafish offspring development and life-long fitness

This study shows that paternal starvation in zebrafish affects offspring metabolism and fitness, with lasting impacts on gene expression and development.

DNA methylation is linked to the monoallelic expression of MRP3, a diatom mating type determining gene

The paper investigates DNA methylation patterns at the mating type locus MRP3 in diatoms, finding that hypomethylation is necessary but not sufficient for MRP3 expression in sexual cells.

De novo and inherited variants in DDX39B cause a Novel Syndrome Characterized by Neurodevelopmental Delay, Short Stature, and Congenital Hypotonia

The paper identifies de novo and inherited variants in DDX39B causing a syndrome with neurodevelopmental delay, short stature, and hypotonia, supported by molecular modeling and functional studies in Drosophila.

Internal Ribosome Entry Sites act as Effector Domain in linear and circular antisense long non-coding SINEUP RNAs

This study identifies SINEUP RNAs with Internal Ribosomal Entry Site (IRES) sequences as effector domains, enhancing translation of target mRNAs through both linear and circular transcripts.

Pgbd5 impacts neuronal differentiation and double strand breaks signaling in the developing cortex

This study shows Pgbd5 is essential for neuronal differentiation and radial migration in mouse corticogenesis, with effects on DNA double-strand breaks and gene expression.

The miR-430 locus with extreme promoter density is a transcription body organizer, which facilitates long range regulation in zygotic genome activation

The paper identifies a high-density miR-430 promoter cluster that forms a transcription body, enabling early gene activation during the minor wave of zygotic genome activation in zebrafish.

The piRNA pathway sustains adult neurogenesis by repressing protein synthesis and cellular senescence

This study shows that the piRNA pathway is essential for adult neurogenesis by repressing protein synthesis and cellular senescence in mouse hippocampal neural progenitor cells.

Identification of LINE retrotransposons and long non-coding RNAs expressed in the octopus brain

The paper identifies LINE retrotransposons and long non-coding RNAs in octopus brains, suggesting their role in cognitive evolution through germline and somatic activity.

Transposable Element activation promotes neurodegeneration in a Drosophila model of Huntington's disease

This study shows that transposable element activation contributes to neurodegeneration in a Drosophila Huntington's disease model and can be inhibited to rescue neurodegeneration and extend lifespan.

Genomics and transcriptomics to unravel sex determination pathway and its evolution in sand flies

The paper identifies sex determination genes in sand flies using genomics and transcriptomics, proposes a model for their sex determination cascade, and characterizes a novel transformer homolog.