Author

Matthew Gribble

Imperial College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Synthetic Biology· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Approach:statistical model· 2

Frequent Co-Authors

Andrea CrisantiiD· 4 shared Austin BurtiD· 4 shared Federica BernardiniiD· 3 shared Tony NolaniD· 3 shared Andrew HammondiD· 2 shared Ioanna MorianouiD· 2 shared Katie WillisiD· 2 shared Lee Phillimore· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersSynthetic Biology

Andrea CrisantiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A male-drive female-sterile system for the self-limited control of the malaria mosquito Anopheles gambiae

Anna Strampelli, Katie Willis, Hannah Robyn Gulliford, Matthew Gribble, Barbara Fasulo, Austin Burt, Andrea Crisanti, Federica Bernardini

This paper proposes a self-limiting gene drive strategy called MDFS to suppress malaria mosquito populations by causing female sterility while allowing fertile males to spread the trait.

Nature Communications · Oct 27, 2025Peer-reviewedMolecular Biology

A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae

Ignacio Tolosana, Katie Willis, Matthew Gribble, Lee Phillimore, Austin Burt, Tony Nolan, Andrea Crisanti, Federica Bernardini

The paper introduces a Y chromosome-linked genome editor (YLE) for population suppression in Anopheles gambiae, showing it is up to 8 times more efficient than other self-limiting strategies.

Nature Communications · Jan 2, 2025Peer-reviewedSynthetic Biology

Engineering Resilient Gene Drives Towards Sustainable Malaria Control: Predicting, Testing and Overcoming Target Site Resistance

Ioanna Morianou, Lee Phillimore, Bhavin S. Khatri, Louise Marston, Matthew Gribble, Austin Burt, Federica Bernardini, Andrew Hammond, Tony Nolan, Andrea Crisanti

The paper presents a pipeline to discover and engineer gene drives that overcome resistance in malaria mosquitoes, showing that new resistant alleles can emerge and designing drives that target multiple sites to suppress populations.

bioRxiv · Oct 21, 2024 · PreprintSynthetic Biology

Regulation of gene drive expression increases invasive potential and mitigates resistance

Andrew Hammond, Xenia Karlsson, Ioanna Morianou, Kyros Kyrou, Andrea K. Beaghton, Matthew Gribble, Nace Kranjc, Roberto Galizi, Austin Burt, Andrea Crisanti, Tony Nolan

This study improves gene drive efficacy by reducing resistance and fitness costs through regulatory sequence modifications, leading to better population suppression and delayed resistance.

bioRxiv · Apr 4, 2020 · PreprintGenetics