A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor loci
Randal Joseph Westrick, Kärt Tomberg, Amy E. Siebert, Guojing Zhu, Mary E. Winn, Sarah L. Dobies, Sara L. Manning, Marisa A Brake, Audrey C. A. Cleuren, Linzi M Hobbs, Lena M. Mishack, Alexander J. Johnston, Emilee N. Kotnik, David R. Siemieniak, Jishu Xu, , David Ginsburg
The paper identifies novel thrombosis suppressor loci using a sensitized mutagenesis screen in Factor V Leiden mice, finding F8 and the Tfpi/F3 axis, as well as Actr2, play key roles in thrombosis regulation.
Proceedings of the National Academy of Sciences · Aug 21, 2017Peer-reviewedGenetics