Author

Sara L. Manning

The University of Texas MD Anderson Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Andrew D. RhimiD· 2 shared Robert W. CowaniD· 2 shared Alexander J. JohnstoniD· 1 shared Amy E. SiebertiD· 1 shared Audrey C. A. CleureniD· 1 shared David Bing ZheniD· 1 shared David GinsburgiD· 1 shared David R. Siemieniak· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersDevelopmental Biology

Andrew D. RhimORCID

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Author profile →

3 papers

Recent·Most cited

Adar1 deletion causes degeneration of exocrine pancreas via Mavs-dependent interferon signaling

Dhwani N. Rupani, Robert W. Cowan, Fredrik I. Thege, Vidhi Chandra, Sonja M. Wörmann, Hajar Rajaei, Prerna Malaney, Olivereen Le Roux, Sara L. Manning, Jack Hashem, Jennifer M. Bailey, Florencia M. McAllister, Andrew D. Rhim

This study shows that Adar1 deletion in mice causes exocrine pancreas degeneration through Mavs-dependent interferon signaling, which is rescued by concurrent Mavs deletion.

Development · Dec 2, 2022Peer-reviewedDevelopmental Biology

Ultra-low Input Circulating Tumor DNA Detection by MED-Amp in Early-Stage Pancreatic Cancer

Erica D. Pratt, David Bing Zhen, Robert W. Cowan, Heather Cameron, Kara A. Schradle, Sara L. Manning, Valerie Gunchick, Diane M. Simeone, Vaibhav Sahai, Andrew D. Rhim

This study evaluates the diagnostic sensitivity of the MED-Amp assay for detecting rare KRAS mutations in ctDNA from localized pancreatic cancer patients, showing improved detection at low DNA input and correlation with survival outcomes.

bioRxiv · Mar 28, 2021 · PreprintGenomics

A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor loci

Randal Joseph Westrick, Kärt Tomberg, Amy E. Siebert, Guojing Zhu, Mary E. Winn, Sarah L. Dobies, Sara L. Manning, Marisa A Brake, Audrey C. A. Cleuren, Linzi M Hobbs, Lena M. Mishack, Alexander J. Johnston, Emilee N. Kotnik, David R. Siemieniak, Jishu Xu, , David Ginsburg

The paper identifies novel thrombosis suppressor loci using a sensitized mutagenesis screen in Factor V Leiden mice, finding F8 and the Tfpi/F3 axis, as well as Actr2, play key roles in thrombosis regulation.

Proceedings of the National Academy of Sciences · Aug 21, 2017Peer-reviewedGenetics