Author

Linda C. Laux

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Assay:electronic health records· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Alfred L. GeorgeiD· 2 shared Dina SimkiniD· 2 shared Evangelos KiskinisiD· 2 shared Brandon N Piyevsky· 1 shared Gabriella L. RobertsoniD· 1 shared Graham T. DempseyiD· 1 shared Hongkang ZhangiD· 1 shared J Gordon MillichapiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Alfred L. GeorgeORCID

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2 papers

Recent·Most cited

Machine Learning Resolves Functional Phenotypes and Therapeutic Responses in KCNQ2 Developmental Epileptic Encephalopathy iPSC Models

Dina Simkin, Syed M.A. Wafa, Mennat Gharib, Kelly A. Marshall, Yezi Yang, Linda C. Laux, Alfred L. George, Evangelos Kiskinis

The paper uses machine learning to analyze iPSC-derived neurons from KCNQ2-DEE patients, identifying functional phenotypes and showing retigabine's variable efficacy in rescuing disease features.

bioRxiv · Jul 26, 2025 · PreprintNeuroscience

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability

Dina Simkin, Timothy J. Searl, Brandon N Piyevsky, Marc P. Forrest, Luis A. Williams, Vaibhav Joshi, Hongkang Zhang, Steven J. Ryan, Michael Schwake, Gabriella L. Robertson, Peter Penzes, Linda C. Laux, Owen B. McManus, Graham T. Dempsey, J Gordon Millichap, , Evangelos Kiskinis

This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.

bioRxiv · Sep 22, 2020 · PreprintNeuroscience