Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability
Dina Simkin, Timothy J. Searl, Brandon N Piyevsky, Marc P. Forrest, Luis A. Williams, Vaibhav Joshi, Hongkang Zhang, Steven J. Ryan, Michael Schwake, Gabriella L. Robertson, Peter Penzes, Linda C. Laux, Owen B. McManus, Graham T. Dempsey, J Gordon Millichap, , Evangelos Kiskinis
This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.
bioRxiv · Sep 22, 2020 · PreprintNeuroscience