Author

Luis A. Williams

Q-State Biosciences (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

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Assay:electronic health records· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Graham T. DempseyiD· 4 shared Steven J. RyaniD· 4 shared Hongkang ZhangiD· 3 shared Owen B. McManusiD· 3 shared Vaibhav Joshi· 3 shared Alfred L. GeorgeiD· 2 shared Amy E. Elder· 2 shared Caitlin L. LewarchiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersNeuroscience

Graham T. DempseyORCID

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4 papers

Recent·Most cited

Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model of SCN2A-Related Disorders

Sashmita Panda, Diana Jazmin Ixmatlahua Ribera, Luis A. Williams, Sheng Tang, Karthiayani Harikrishnan, Vaibhav Joshi, Steven J. Ryan, Chinwendu Obi Obasi, Linda Laux, Enrique Rojas, Owen Mcmanus, Graham T. Dempsey, Alfred L. George, Scott K. Adney

This study examines the impact of a SCN2A pathogenic variant in human neurons using electrophysiology and machine learning, showing that sodium channel blockers can restore normal function.

bioRxiv · May 19, 2026 · PreprintNeuroscience

Discovery of novel compounds and target mechanisms using a high throughput, multiparametric phenotypic screen in a human neuronal model of Tuberous Sclerosis

Luis A. Williams, Steven J. Ryan, Vaibhav Joshi, Caitlin L. Lewarch, Amy E. Elder, Owen B. McManus, Patrice Godard, Srinidhi Sridhar, Jane Jacques, Jennifer Grooms, James J. Fink, Hongkang Zhang, Michel R. Gillard, Cécile Pégurier, Yogesh A. Sabnis, , Graham T. Dempsey

The paper identifies chemical scaffolds that rescue functional TSC disease parameters through a phenotypic screen in a human neuronal model of Tuberous Sclerosis.

bioRxiv · Feb 22, 2024 · PreprintNeuroscience

A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology

Pin W. Liu, Hongkang Zhang, Christopher A. Werley, Monika Pichler, Steven J. Ryan, Caitlin L. Lewarch, Jane Jacques, Jennifer Grooms, Jean Ferrante, Guangde Li, Dawei Zhang, Nate Bremmer, Adam Barnett, Romina Chantre, Amy E. Elder, , Owen B. McManus

The paper presents an in vitro model of OA pain using SPARC and a high-throughput all-optical electrophysiology system to screen drugs for pain relief.

Pain · Nov 14, 2023Peer-reviewedNeuroscience

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability

Dina Simkin, Timothy J. Searl, Brandon N Piyevsky, Marc P. Forrest, Luis A. Williams, Vaibhav Joshi, Hongkang Zhang, Steven J. Ryan, Michael Schwake, Gabriella L. Robertson, Peter Penzes, Linda C. Laux, Owen B. McManus, Graham T. Dempsey, J Gordon Millichap, , Evangelos Kiskinis

This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.

bioRxiv · Sep 22, 2020 · PreprintNeuroscience