Graham T. Dempsey

This study examines the impact of a SCN2A pathogenic variant in human neurons using electrophysiology and machine learning, showing that sodium channel blockers can restore normal function.

The paper identifies chemical scaffolds that rescue functional TSC disease parameters through a phenotypic screen in a human neuronal model of Tuberous Sclerosis.

The paper presents an in vitro model of OA pain using SPARC and a high-throughput all-optical electrophysiology system to screen drugs for pain relief.

This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.

~2-4x SNR gains and 20-300x compression on calcium and voltage imaging, from a patch-wise penalized matrix decomposition that splits signal from temporally uncorrelated noise without hyperparameter tuning.