Owen B. McManus

Discovery of novel compounds and target mechanisms using a high throughput, multiparametric phenotypic screen in a human neuronal model of Tuberous Sclerosis

The paper identifies chemical scaffolds that rescue functional TSC disease parameters through a phenotypic screen in a human neuronal model of Tuberous Sclerosis.

A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology

The paper presents an in vitro model of OA pain using SPARC and a high-throughput all-optical electrophysiology system to screen drugs for pain relief.

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability

This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.