Author

Vaibhav Joshi

Q-State Biosciences (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Assay:electronic health records· 3 Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Graham T. DempseyiD· 3 shared Luis A. Williams· 3 shared Steven J. RyaniD· 3 shared Alfred L. GeorgeiD· 2 shared Hongkang ZhangiD· 2 shared Owen B. McManusiD· 2 shared Amy E. Elder· 1 shared Brandon N Piyevsky· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Graham T. DempseyORCID

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Author profile →

3 papers

Recent·Most cited

Excitatory Dysfunction and Phenotypic Rescue in a Human Neuronal Model of SCN2A-Related Disorders

Sashmita Panda, Diana Jazmin Ixmatlahua Ribera, Luis A. Williams, Sheng Tang, Karthiayani Harikrishnan, Vaibhav Joshi, Steven J. Ryan, Chinwendu Obi Obasi, Linda Laux, Enrique Rojas, Owen Mcmanus, Graham T. Dempsey, Alfred L. George, Scott K. Adney

This study examines the impact of a SCN2A pathogenic variant in human neurons using electrophysiology and machine learning, showing that sodium channel blockers can restore normal function.

bioRxiv · May 19, 2026 · PreprintNeuroscience

Discovery of novel compounds and target mechanisms using a high throughput, multiparametric phenotypic screen in a human neuronal model of Tuberous Sclerosis

Luis A. Williams, Steven J. Ryan, Vaibhav Joshi, Caitlin L. Lewarch, Amy E. Elder, Owen B. McManus, Patrice Godard, Srinidhi Sridhar, Jane Jacques, Jennifer Grooms, James J. Fink, Hongkang Zhang, Michel R. Gillard, Cécile Pégurier, Yogesh A. Sabnis, , Graham T. Dempsey

The paper identifies chemical scaffolds that rescue functional TSC disease parameters through a phenotypic screen in a human neuronal model of Tuberous Sclerosis.

bioRxiv · Feb 22, 2024 · PreprintNeuroscience

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability

Dina Simkin, Timothy J. Searl, Brandon N Piyevsky, Marc P. Forrest, Luis A. Williams, Vaibhav Joshi, Hongkang Zhang, Steven J. Ryan, Michael Schwake, Gabriella L. Robertson, Peter Penzes, Linda C. Laux, Owen B. McManus, Graham T. Dempsey, J Gordon Millichap, , Evangelos Kiskinis

This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.

bioRxiv · Sep 22, 2020 · PreprintNeuroscience