Mark M. Youssef

Expanding GABAergic Neuronal Diversity in PSC-Derived Disease Models

This study develops a method to generate diverse GABAergic neurons from PSCs using TFs and signaling inhibition, showing distinct subtype compositions and disease relevance.

Alcohol reverses the effects of KCNJ6 (GIRK2) noncoding variants on excitability of human glutamatergic neurons

This study shows that KCNJ6 noncoding variants increase excitability in human glutamatergic neurons, an effect reversed by ethanol exposure.

The amyloid precursor protein modulates the position and length of the axon initial segment offering a new perspective on Alzheimer's disease genetics

This paper shows that full-length APP affects axon initial segment structure, linking APP function to Alzheimer's disease without relying on Aβ.