A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge Of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8
K. V. Tarasov, K. Chakir, D. R. Riordon, A. E. Lyashkov, I. Ahmet, M. G. Perino, A. J. Silvester, J. Zhang, M. Wang, Y. O. Lukyanenko, J.-H. Qu, M. C.-R. Barrera, M. Juhaszova, Y. S. Tarasova, B. Ziman, , E. G. Lakatta
This study shows that cardiac-specific overexpression of AC8 in mice leads to adaptive cardiac changes resembling cancer-like survival mechanisms without heart failure.
bioRxiv · May 20, 2022Physiology