L. Kremer

The diversity of clinical Mycobacterium abscessus isolates in morphology, glycopeptidolipids and infection rates in a macrophage model

This study examines the relationship between morphology, glycopeptidolipids, and infectivity in Mycobacterium abscessus clinical isolates using macrophage models.

Mycobacterium trehalose polyphleates are required for infection by therapeutically useful mycobacteriophages BPs and Muddy

This study shows that trehalose polyphleates are essential for phage infection of Mycobacterium species and that phage resistance can arise through TPP loss or mutations in phage tail spike proteins.

C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus

This study develops a C25-modified rifamycin derivative, 5j, which resists enzymatic inactivation by ArrMab and shows potent antimicrobial activity against M. abscessus in vitro and in macrophages.

Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline

The paper shows that combining epetraborole with norvaline enhances efficacy against Mycobacterium abscessus in a murine model.

Modelling the interaction between Infectious Bursal Disease Virus VP3 polypeptide and dsRNA: identification of key residues for ribonucleoprotein assembly and virus replication

This study identifies key residues in IBDV VP3 for dsRNA binding and virus replication by analyzing mutant versions and their effects on ribonucleoprotein assembly and host evasion.

Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection of adult zebrafish

This study compares immune responses to smooth and rough variants of Mycobacterium abscessus in zebrafish, showing differential control by host immunity.

Adaptive mitochondrial regulation of the proteasome

This study shows mitochondrial dysfunction reduces 26S proteasome assembly and activity, which can be reversed by aspartate or pyruvate supplementation.

Glycosylation-dependent enhanced cell-binding and infectivity through DC-SIGN in the West African Ebola virus Makona

This study identifies a glycosylation-dependent enhancement in the binding and infectivity of the EBOV Makona variant through DC-SIGN, contributing to its rapid spread during the 2013-2016 West African epidemic.

Genetically Targeted Ratiometric and Activated pH Indicator Complexes (TRApHIC) for Receptor Trafficking

The paper develops TRApHIC, a genetically targeted pH sensor for studying receptor trafficking, revealing agonist-specific differences in B2AR endocytosis and recycling.