M. J. Trnka

In-cell chemical crosslinking identifies hotspots for p62-IκBα interaction that underscore a critical role of p62 in limiting NF-κB activation through IκBα-stabilization

This study identifies p62-IκBα interaction hotspots using in-cell crosslinking and proteomics, revealing p62 stabilizes IκBα to limit NF-κB activation and prevent liver inflammation.

Activation of Histone 3 Lysine 9 methyl writing and reading capabilities within the G9a-GLP heterodimer

This study shows that the G9a-GLP heterodimer enhances H3K9 methylation reading and writing compared to homodimers, with increased turnover and recognition of H3K9me2.

SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA

This study shows that SARS-CoV-2 nucleocapsid protein forms condensates with viral RNA in vitro and in cells, driven by hydrophobic and electrostatic interactions.

A NOVEL MECHANISM FOR NF-κB-ACTIVATION VIA IκB-AGGREGATION: IMPLICATIONS FOR HEPATIC MALLORY-DENK-BODY INDUCED INFLAMMATION

This study identifies a novel mechanism of NF-κB activation through IκB sequestration into insoluble aggregates along with aggregation-prone proteins in MDB-inducing models.

Disorganization of the histone core promotes organization of heterochromatin into phase-separated droplets

This study shows that the S. pombe HP1 protein Swi6 promotes chromatin compaction through phase-separated droplets by disorganizing the histone core and increasing histone residue accessibility.