Author

S. Tejpar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 8 Research Focus:differential expression· 8 Organism:human· 8 Assay:bulk RNA-seq· 6 Approach:experimental assay· 5 Approach:deep learning· 4 Organism:mouse· 4 Assay:scRNA-seq· 4

Frequent Co-Authors

Y. Hong· 3 shared A. D. Campbell· 2 shared A. D. Garg· 2 shared D. Lambrechts· 2 shared F. De Smet· 2 shared F. M. Bosisio· 2 shared I. Vanmeerbeek· 2 shared J. Borst· 2 shared

Activity by Year

2017-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

Y. Hong

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11 papers

Recent·Most cited

A lymph node-to-tumour PD-L1+macrophage circuit antagonizes dendritic cell immunotherapy

J. Sprooten, I. Vanmeerbeek, A. Datsi, J. Govaerts, D. Borras, S. Naulaerts, R. Laureano, A. Calvet, M. Kuballa, M. Sabel, M. Rapp, C. Knobbe-Thomsen, P. Liu, L. Zhao, O. Kepp, , A. D. Garg

This paper shows that DC vaccines can activate PD-L1+ macrophages in lymph nodes and tumors, creating an immunosuppressive circuit that limits their effectiveness, but this can be overcome by combining with PD-L1 blockade.

Cell Reports Medicine · Jan 1, 2024Peer-reviewedImmunology

Interpretable Inflammation Landscape of Circulating Immune cells

L. Jimenez-Gracia, D. Maspero, S. Aguilar-Fernandez, F. Craighero, M. Boulougouri, M. Ruiz, D. Marchese, G. Caratu, J. Linares-Blanco, M. Berasategi, R. O. Ramirez Flores, A. Sanzo-Machuca, A. M. Corraliza, H. A. Tran, R. Normand, , Na

This paper constructs a single-cell atlas of circulating immune cells to understand inflammation across diseases and develops a classifier for inflammatory diseases.

bioRxiv · Nov 28, 2023Immunology

Colibactin-induced genotoxicity and colorectal cancer exacerbation critically depends on adhesin-mediated epithelial binding

M. Jans, M. Kolata, G. Blancke, M. Ciers, A. B. Dohlman, T. Kusakabe, M. Sze, A. Thiran, G. Berx, S. Tejpar, G. van Loo, I. D. Iliev, H. Remaut, L. Vereecke

This study shows that pks+ E. coli's ability to worsen colorectal cancer depends on adhesins that allow it to bind to host cells and produce the genotoxin colibactin.

bioRxiv · Aug 16, 2023 · PreprintCancer Biology

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

J. Deng, T. Pan, Y. Hong, Z. Liu, X. Zhou, Z. An, L. Li, G. Alfano, G. Li, L. Dolcetti, R. Evans, J. M. Vicencio, P. Vlckova, Y. Chen, J. Monypenny, , T. Ng

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

bioRxiv · Aug 10, 2023 · PreprintCancer Biology

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

L. van Baarle, V. De Simone, L. Schneider, S. Santhosh, S. Abdurahiman, F. Biscu, R. Schneider, L. Zanoletti, S. Verbandt, Z. Hu, M. Stakenborg, B.-J. Ke, B. Garcia-Reyes, J. Henn, M. Toma, , G. Matteoli

This study identifies IL-1R signaling as a driver of enteric glia-macrophage interactions in colorectal cancer, promoting tumor progression through IL-6 secretion.

bioRxiv · Jun 1, 2023Cancer Biology

Molecular portraits of colorectal cancer morphological regions

E. Budinska, M. Hrivnakova, T. Catela Ivkovic, M. Madrzyk, R. Nenutil, B. Bencsikova, D. Al Tukmachi, M. Ruckova, L. Zdrazilova Dubska, O. Slaby, J. Feit, M.-P. Dragomir, P. Borilova Linhartova, S. Tejpar, V. Popovici

The paper investigates how morphological patterns in colorectal cancer influence molecular profiles and shows that morphotype-based sampling reveals molecular features missed by whole-tumor analysis.

bioRxiv · Jan 24, 2023Cancer Biology

Mutation-induced phenotypic plasticity drives formation of a pro-metastatic tumour-intrinsic niche

J. M. Bugter, L. El Bouazzaoui, E. Kucukkose, M. L. Mills, Y. Hong, J. Sprangers, I. Jordens, D. Kokkinidi, S. Plugge, A. Venhuizen, S. Bosman, J. Hageman, N. Fenderico, K. Gilroy, D. Montiel Gonzalez, , M. M. Maurice

This study identifies mutation-induced phenotypic plasticity as a driver of a pro-metastatic tumour-intrinsic niche in BRAF-mutant colorectal cancer.

bioRxiv · Dec 22, 2022 · PreprintCancer Biology

Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture

E. Gil Vazquez, N. Nasreddin, G. N. Valbuena, E. J. Mulholland, H. L. Belnoue-Davis, H. Eggington, R. O. Schenck, V. M. Wouters, P. Wirapati, K. Gilroy, T. R. M. Lannagan, D. J. Flanagan, A. K. Najumudeen, S. Omwenga, A. M. B. McCorry, , S. J. Leedham

The paper examines stem cell population dynamics in colorectal tumors, showing that CBC-RSC admixture correlates with mutations and microenvironmental changes, and is linked to chemoresistance.

bioRxiv · Jun 11, 2022Cancer Biology

Immunogenomic, single-cell and spatial dissection of CD8+T cell exhaustion reveals critical determinants of cancer immunotherapy

S. Naulaerts, D. M. Borras, A. A. Martinez, J. Messiaen, Y. Van Herck, L. Gelens, T. Venken, I. Vanmeerbeek, S. More, J. Sprooten, O. Bechter, G. Bergers, A. Liston, S. De Vleeschouwer, B. J. Van den Eynde, , A. D. Garg

This study identifies distinct CD8+T cell states in cancer patients using multi-omics data, showing that dysfunctional states resist immunotherapy while exhausted states can be targeted with specific treatments.

bioRxiv · Nov 22, 2021Immunology

A Pan-Cancer Blueprint of the Heterogeneous Tumour Microenvironment Revealed by Single-Cell Profiling

J. Qian, S. Olbrecht, B. Boeckx, H. Vos, D. Laoui, E. Etlioglu, E. Wauters, V. Pomella, S. Verbandt, P. Busschaert, A. Bassez, A. Franken, M. Vanden Bempt, J. Xiong, B. Weynand, , D. Lambrechts

This study profiles single cells from multiple cancer types to create a pan-cancer blueprint of stromal cell heterogeneity, identifying shared and unique cell populations and their characteristics.

bioRxiv · Apr 1, 2020Cancer Biology

Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer

P. D. Dunne, H. G. Coleman, P. Bankhead, M. Alderdice, R. T. Gray, S. McQuaid, V. Bingham, M. B. Loughrey, J. A. James, A. M. McCorry, A. Gilmore, C. Holohan, D. Klingbiel, S. Tejpar, P. G. Johnston, , M. Lawler

The paper identifies Bcl-xL as a prognostic biomarker and predictor of response to adjuvant chemotherapy in BRAF-mutant stage II/III colon cancer using gene expression and immunohistochemistry validation.

bioRxiv · Oct 23, 2017Cancer Biology