Author

M. B. Sheppard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Daugherty· 2 shared J. D. Smith· 2 shared J. Z. Chen· 2 shared A. E. Mullick· 1 shared D. A. Howatt· 1 shared G. Matyas· 1 shared H. S. Lu· 1 shared H. Sawada· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersPhysiology

A. Daugherty

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3 papers

Recent·Most cited

Novel Insights into the Aortic Mechanical Properties of Mice Modeling Hereditary Aortic Diseases

N. Dubacher, K. Sugiyama, J. D. Smith, V. Nussbaumer, M. Csonka, S. Ferenczi, K. J. Kovacs, S. M. Caspar, L. Lamberti, J. Meienberg, H. Yanagisawa, M. B. Sheppard, G. Matyas

This paper measures aortic rupture force in mouse models of hereditary aortic diseases to assess biomechanical integrity and drug effects.

bioRxiv · Aug 15, 2023Pathology

Losartan Increases Survival of the Fbn1mgR/mgR Mouse Model of Marfan Syndrome in and Age-Dependent Manner

J. D. Smith, J. Z. Chen, R. Phillip, A. Daugherty, M. B. Sheppard

This study shows that losartan improves survival in male Fbn1mgR/mgR mice when started at 50 days old but not at 24 days, while no benefit was seen in females.

bioRxiv · Feb 19, 2021 · PreprintPhysiology

Inhibition of Angiotensin II Dependent AT1a Receptor Stimulation Attenuates Thoracic Aortic Pathology in Fibrillin-1C1041G/+ Mice

J. Z. Chen, H. Sawada, J. J. Moorleghen, M. K. Franklin, D. A. Howatt, M. B. Sheppard, A. E. Mullick, H. S. Lu, A. Daugherty

This study shows that inhibiting the AngII-AT1aR axis reduces aortic pathology in male Fbn1C1041G/+ mice, suggesting ligand-dependent AT1aR stimulation contributes to TAA progression.

bioRxiv · Jun 1, 2020Physiology